What is a binding domain?
What is a binding domain?
A binding domain is a protein domain which binds to a specific atom or molecule, such as calcium or DNA.
What is the ligand binding domain of the endocrine system?
The domain responsible for hormone binding is the ligand binding domain (LBD). This domain participates in several activities including hormone binding, homo- and/or heterodimerization, formation of the heat-shock protein complex and transcriptional activation and repression.
What are the different ways to classify a ligand?
Ligands are classified in many ways, including: charge, size (bulk), the identity of the coordinating atom(s), and the number of electrons donated to the metal (denticity or hapticity).
How do antagonist ligands bind to corepressor proteins?
Binding of antagonist ligands to nuclear receptors in contrast induces a conformation of the receptor that preferentially binds corepressor proteins. These proteins, in turn, recruit histone deacetylases (HDACs), which strengthens the association of histones to DNA, and therefore represses gene transcription.
