What is Apo Transferrin?
What is Apo Transferrin?
The iron-free protein apotransferrin is a single-chain glycoprotein (mol wt 79 570) with two nonidentical iron-binding sites that have a high affinity for ferric iron under physiological conditions (effective stability constant, 1024 mol l−1). Plasma apotransferrin is synthesized predominantly in the liver.
Where is Apotransferrin found?
Plasma apotransferrin is synthesized predominantly in the liver. It exists in the plasma in the iron-free form or as monoferric or diferric transferrin since iron loading at each binding site is a random process.
Is transferrin the same as ferritin?
Ferritin is stored in the body’s cells until it’s time to make more red blood cells. The body will signal the cells to release ferritin. The ferritin then binds to another substance called transferrin. Transferrin is a protein that combines with ferritin to transport it to where new red blood cells are made.
What is the role of Apoferritin?
Apoferritin is a protein commonly present in the intestinal mucosa membrane. The important biological function of apoferritin is its ability to bind and store iron, by combining with a ferric hydroxide–phosphate compound to form ferritin.
What happens when your transferrin is high?
The normal range for transferrin is 204 to 360 mg/dl. If you have a higher amount, you may have iron-deficiency anemia. If you have a lower level, you may have another problem, such as liver disease and hemolytic anemia. Transferrin may also be measured using a value called total iron-binding capacity (TIBC).
What is true about ferritin and transferrin?
What is the difference between ferritin and Apoferritin?
Ferritin is a universal intracellular protein that stores iron and releases it in a controlled fashion. Ferritin is a globular protein complex consisting of 24 protein subunits forming a hollow nanocage with multiple metal–protein interactions. Ferritin that is not combined with iron is called apoferritin.
