What is considered a high intensity statin?
What is considered a high intensity statin?
High-intensity statin was defined as atorvastatin administered at 40–80 mg, rosuvastatin at 20–40 mg, or simvastatin at 80 mg, i.e., medication amounts higher than the standard doses described in recent guidelines [8, 9].
Which statin is the strongest?
Rosuvastatin and atorvastatin are the strongest statins because they have long half-lives. – Atorvastatin, simvastatin, and lovastatin are metabolized by the P450 cytochrome 3A4, which is inhibited by many other drugs and may thereby increase the risk of myopathy.
How much do high intensity statins lower LDL?
High intensity statins typically reduce LDL-C by 50% or more; this percentage reduction occurs regardless of baseline levels of LDL-C. This explains why the guidelines set a goal for LDL-C secondary prevention to be a > 50% reduction in levels.
Is atorvastatin 40mg high intensity?
— High-intensity statin therapies are atorvastatin (40–80 mg) or rosuvastatin (Crestor; 20–40 mg). Moderate-intensity statin therapies include atorvastatin (10–20 mg), rosuvastatin (5–10 mg), simvastatin (20–40 mg), pravastatin (40–80 mg), and several others.
What are the two high intensity statins?
Atorvastatin 40 or 80 mg and rosuvastatin 20 mg were defined as high‐intensity statins, and the other statins were classified as non‐high‐intensity statins.
What are moderate and high intensity statins?
Statin Use for the Prevention of Cardiovascular Disease in Adults: A Systematic Review for the U.S. Preventive Services Task Force [Internet]….Table 1Statin Dosing and ACC/AHA Classification of Intensity.
| Statin | Atorvastatin | |
|---|---|---|
| Dosage | Low-intensity (LDL-C reduction <30%) | NA |
| Moderate-intensity (LDL-C reduction 30% to <50%) | 10 to 20 mg | |
| High-intensity (LDL-C reduction >50%) | 40 to 80 mg |
Is rosuvastatin stronger than atorvastatin?
At the end of the titration-to-goal period, rosuvastatin was significantly more effective than atorvastatin on the primary efficacy measure, reducing LDL-C by 52% compared with 46% in the atorvastatin group (p < 0.0001) (table 2).
Is rosuvastatin stronger than simvastatin?
Dosage and strength Both Crestor and simvastatin come in a range of strengths. However, the doses between Crestor and simvastatin are not equivalent. Crestor is a lot more potent. For example, 40 mg is a high dose of simvastatin, but you would get that same dose of Crestor in about 10 mg.
When do you start high-intensity statin?
While prior guidelines suggested high-intensity statins for patients with diabetes if their 10-year ASCVD risk is ≥7.5%, the current guidelines recommend initiating high-intensity statin for those with the presence of multiple risk factors to reduce LDL-C levels by ≥50%.
What is the difference between rosuvastatin and simvastatin?
Aside from being better at lowering so-called “bad” cholesterol levels in the bloodstream, another advantage to rosuvastatin is that it has far fewer negative interactions with other medications than simvastatin, or most other statins, for that matter.
What is high intensity atorvastatin?
Definitions: *High Intensity Statin Therapy–defined as dose expected to reduce LDL- C by greater than or equal to 50% and includes the following: (1,2) Atorvastatin 40-80mg everyday. Rosuvastatin 20-40mg everyday.
What is the best moderate-intensity statin?
High-, Moderate-, and Low-Intensity Statin Therapy Recommended by the ACC/AHA Guideline
| High-intensity statin therapy* | Moderate-intensity statin therapy* |
|---|---|
| Rosuvastatin (Crestor), 20 mg | Fluvastatin, 40 mg twice daily |
| Lovastatin, 40 mg | |
| Pravastatin (Pravachol), 40 mg | |
| Rosuvastatin, 10 mg |
What is moderate to high intensity statin?
High-Intensity Statin Therapy Offers Survival Benefit Over Moderate-Intensity Statins in CVD Patients. Treatment with a high-intensity statin, which includes rosuvastatin 20 or 40 mg and atorvastatin 40 or 80 mg, was associated with a 9% reduction in the risk of death at 1 year compared with taking a moderate-intensity statin.
What is a high dose for statin?
High-dose statins included rosuvastatin (Crestor) at doses of 10 milligrams (mg) or higher, atorvastatin (Lipitor) at doses of 20 mg or higher and simvastatin (Zocor) at doses of 40 mg. All other statin doses were considered low dose.
What is a low dose statin?
Statins – Low Dose. Statins, originally felt to work solely as an inhibitor of cholesterol biosynthesis, now appear to work independently of cholesterol reduction. Adding to cholesterol’s innocence is its vital role in the body – mediator of synaptic transmissions, precursor of vital hormones and the most abundant biochemical in our brains.
What is high intensity interval?
High-intensity interval training ( HIIT) describes any workout that alternates between intense bursts of activity and fixed periods of less-intense activity or even complete rest. For example, a good starter workout is running as fast as you can for 1 minute and then walking for 2 minutes.
