What is EGFR in cancer?
What is EGFR in cancer?
What is EGFR-positive cancer? EGFR (epidermal growth factor receptor) is a protein on cells that helps them grow. A mutation in the gene for EGFR can make it grow too much, which can cause cancer. There are different types of EGFR mutations.
What is the ligand for EGFR?
Betacellulin (BTC) is a dual-specificity ligand that binds to and activates EGFR and ERBB4.
What is a good EGFR?
A normal eGFR is 60 or more. If your eGFR is less than 60 for three months or more, your kidneys may not be working well. Use this chart to see what your eGFR may mean.
What does binding of EGF to EGFR do?
Binding of EGF to the EGFR leads to the transphosphorylation of various tyrosine residues on the intracellular C-terminal tail. The tyrosine residues phosphorylated by EGF addition to cells include Y703, Y920, Y992, Y1045, Y1068, Y1086, Y1148, and Y1173.
What is HER1 and HER2?
HER1 (also known as EGFR or ErbB1) and HER2 (also known as ErbB2) belong to the ErbB family of signaling proteins, which comprises four members: HER1, HER2, ErbB3 and ErbB4. ErbB receptors are often amplified, mutated and/or overexpressed in breast cancer (4,5).
What is the normal range of EGFR in adults?
In adults, the normal eGFR number is more than 90. eGFR declines with age, even in people without kidney disease. See chart below for average estimated eGFR based on age. Age (years) Average estimated eGFR. 20–29.
What is the role of TGF-alpha in hepatic fibrosis?
TGF-alpha may attenuate hepatic fibrosis in part because of upregulation of the expression of MMP-1. In NCI-H292 tumor cells, TGF-alpha stimulation induces two phases of epidermal growth factor receptor (EGFR) phosphorylation. The second EGFR phosphorylation is TACE-dependent and is responsible for most of the total mucin induced by TGF-alpha.
What is tgtgfa transforming growth factor alpha?
TGFA transforming growth factor alpha [ (human)] Summary. This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development.
What does it mean when your GFR is over 60?
A GFR below 60 for three months or more or a GFR above 60 with kidney damage (marked by high levels of albumin in your urine) indicates chronic kidney disease. Your doctor will want to investigate the cause of your kidney disease and continue to check your kidney function to help plan your treatment.
