What is eplerenone used to treat?

What is eplerenone used to treat?

Eplerenone belongs to the general class of medicines called antihypertensives. It is used alone or together with other medicines to treat high blood pressure (hypertension). This medicine is also used to treat congestive heart failure (CHF) after a heart attack.

What is eplerenone generic for?

Eplerenone oral tablet is available as a generic drug and a brand-name drug. Brand name: Inspra. Eplerenone comes only as a tablet you take by mouth. Eplerenone oral tablet is used to treat hypertension (high blood pressure), and heart failure after you have a heart attack.

Is eplerenone better than spironolactone?

In summary, the data of eplerenone use in resistant HTN are encouraging but currently appear to trail those reported with the use of spironolactone. However, for patients developing anti-androgenic side effects from spironolactone, eplerenone is efficacious and better tolerated and thus a good alternative.

What is eplerenone 50mg?

Eplerenone is used to treat your heart failure to prevent worsening and reduce hospitalisations if you: have had a recent heart attack, in combination with other drugs that are used to treat your heart failure, or. have persistent, mild symptoms despite the treatment you have been receiving so far.

What is eplerenone 25mg?

Eplerenone is a blood pressure medicine. It’s used to treat heart failure and reduce the risk of you having other heart problems or a stroke. It also helps to stop heart failure getting worse. It can sometimes be used to treat a condition called hyperaldosteronism.

Does eplerenone affect heart rate?

There was no effect of eplerenone on heart rate. At the lower doses of 50 mg and 100 mg/d, twice-daily dosing (ie, 25 mg bid and 50 mg bid) reduced seated systolic and diastolic blood pressures to a greater extent than did once-daily dosing. Eplerenone also significantly decreased ambulatory blood pressure.

How long should you use eplerenone?

Your doctor may start you on a low dose of eplerenone and increase your dose after 4 weeks. Eplerenone controls high blood pressure but does not cure it. It may take 4 weeks or longer before you feel the full benefit of eplerenone. Continue to take eplerenone even if you feel well.

How does eplerenone differ from spironolactone?

Pharmacological differences between spironolactone and eplerenone include lower affinity of eplerenone for progesterone, androgen, and glucocorticoid receptors; more consistently demonstrated nongenomic properties for eplerenone; and the presence of long-acting metabolites for spironolactone.

What is the advantage of eplerenone over spironolactone?

A major advantage of eplerenone over the nonselective aldosterone receptor antagonist spironolactone is lack of binding to progesterone and androgen receptors, which is associated with drug-induced gynecomastia, breast pain, and impotence.

Does eplerenone cause erectile dysfunction?

The most common reported adverse events in patients receiving eplerenone was headache (11.6%); however, the frequency was not significantly higher than in those receiving placebo. One patient each in the eplerenone 100 mg and placebo group experienced impotence (6).

Is eplerenone more expensive than spironolactone?

Therefore, eplerenone is approximately 6 to 7 times more expensive than spironolactone for the treatment of either hypertension or congestive heart failure.