What is foscarnet prescribed for?
What is foscarnet prescribed for?
Foscarnet injection is used to treat symptoms of cytomegalovirus (CMV) infection of the eyes in patients with acquired immune deficiency syndrome (AIDS). Foscarnet will not cure CMV eye infection, but it may help to control worsening of the symptoms.
What kind of drug is foscarnet?
Foscarnet is in a class of medications called antivirals. It works by slowing the growth of CMV and HSV. Foscarnet controls CMV retinitis and HSV infections of the skin and mucus membranes but does not cure these infections.
How long does foscarnet take to work?
It is usually infused slowly over 1 to 2 hours using an infusion pump.
How is foscarnet nephrotoxic?
Deray et al. have shown that foscarnet is a highly nephrotoxic drug which induces acute tubular necrosis [28]. More recently, A. Wallin and A. Ryrfeldt have suggested that the toxic effects of foscarnet may be due to its ability to form poorly soluble complexes with divalent cations [29].
How long should I give my cat famciclovir?
Dosage and Administration of Famciclovir Dosing is commonly 250-500mg per dose twice daily for two weeks. If your pet is experiencing severe ocular symptoms, an antiviral eye drop may also be prescribed.
What is Lamivudine and Tenofovir Disoproxil Fumarate Tablets for?
This combination product is used with other HIV medications to help control HIV infection. It helps to decrease the amount of HIV in your body so your immune system can work better. This lowers your chance of getting HIV complications (such as new infections, cancer) and improves your quality of life.
How much D5 and NS should be given with foscarnet?
With subsequent doses, administer 500-1000ml of D5 or NS concurrently with the foscarnet. In patients with fluid overload, less (but not none) hydration may be given, recognizing the associated increased risk of nephrotoxicity.
How should I administer foscarnet?
– Infusion site: Infusion through a central line is recommended when available. If infusing through a peripheral line, the solution must be diluted to £12 mg/ml. – Hydration: Ensuring adequate hydration is essential to mitigating the nephrotoxicity of foscarnet. Before the initial dose, administer 750-1000ml of D5 or NS over 1 hour.
How often can you give foscarnet to a child?
Infants† and Children†. As an alternative to ganciclovir (first choice), foscarnet 60 mg/kg/dose IV every 8 hours (or 90 mg/kg/dose IV every 12 hours) for 2 to 3 weeks as induction therapy, then 90 to 120 mg/kg/dose IV once daily as chronic suppression.
How often do you give foscarnet for HIV?
Intravenous dosage. Induction with 90 mg/kg/dose IV every 12 hours or 60 mg/kg/dose IV every 8 hours for 14 to 21 days, depending upon the clinical response. The HIV guidelines suggest foscarnet as second-line induction therapy; induction should be followed-up with chronic maintenance therapy (secondary prophylaxis).
