What is GIST leiomyoma?

What is GIST leiomyoma?

DISCUSSION. GISTs are rare neoplasms that account for less than 1% of all gastrointestinal malignancies. GISTs have the capability to become malignant and then metastasize, whereas leiomyomas are almost invariably benign[4].

What is DOG1 antibody?

DOG1 antibody is a highly sensitive and specific marker for gastrointestinal stromal tumors in cytology cell blocks.

What does CD117 positive mean?

Other mesenchymal tumors that were variably CD 117 positive included clear cell sarcoma (7 of 15), metastatic melanoma (9 of 25), and malignant fibrous histiocytoma (1 of 20). These results indicate that CD117 is a specific marker for GIST among tumors that occur in the GI tract and adjacent regions.

Is a GIST cancerous?

What are GISTs? Cancer can start any place in the body. A GIST (pronounced “jist”) is an uncommon type of cancer that starts in the digestive tract, also known as the gastrointestinal (GI) tract. This is the path inside our body that food passes through.

What is GIST disease?

Gastrointestinal stromal tumors (GISTs) are uncommon cancers that start in special cells in the wall of the gastrointestinal (GI) tract, also known as the digestive tract.

What is Carney’s triad?

Carney triad is a rare condition that describes the occurrence of three kinds of endocrine tumors in the same child. The tumors comprising the triad are tumors in the gastrointestinal tract (known as gastrointestinal stromal tumors, or GIST), pulmonary chondromas, and paragangliomas.

Is C-kit the same as CD117?

The CD117 gene, officially known as “KIT proto-oncogene receptor tyrosine kinase” (GenBank ID: 3815), is also more commonly known as c-kit, kit, or stem cell factor receptor. CD117 was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit.

Do GISTs spread?

GIST cells can sometimes spread to other parts of the body. For instance, GIST cells in the stomach might travel to the liver and grow there. When cancer cells do this, it’s called metastasis. To doctors, the cancer cells in the new place look just like the ones from the stomach.

Which mesenchymal tumors are associated with dog1-positive leiomyomas?

DOG1 was highly specific for GIST, but exceptional DOG1-positive other mesenchymal tumors included uterine type retroperitoneal leiomyomas, peritoneal leiomyomatosis, and synovial sarcomas (positive in 5/42, 4/17, and 6/37 cases). Leiomyomas colonized by DOG1-positive Cajal cells should not be confused with GISTs.

Which GISTs are dog1-positive?

All GISTs and selected non-GISTs were independently evaluated for KIT. In the GI tract, Cajal cells and gastric surface epithelia were DOG1-positive. The overall sensitivity of DOG1 and KIT in GISTs was nearly identical: 94.4% and 94.7%, and results in GISTs were generally concordant.

What are leiomyomas of muscularis mucosae of colon and rectum?

Mesenchymal tumors of muscularis mucosae of colon and rectum are benign leiomyomas that should be separated from gastrointestinal stromal tumors—a clinicopathologic and immunohistochemical study of eighty-eight cases. Mod Pathol. 2001 Oct;14 (10):950-6.