What is hCG free beta chain test?
What is hCG free beta chain test?
This screening is done by a combination of two biochemical markers i.e. serum free β-human chorionic gonadotrophin (free β-hCG) and pregnancy associated plasma protein A (PAPP-A), maternal age and fetal nuchal translucency (NT) thickness at 11 + 0–13 + 6 weeks of gestation.
What causes high free beta-hCG levels in pregnancy?
Causes may include a placental tumor or molar pregnancy, in which a non-viable egg implants in the uterus and secretes the hCG hormone. Higher levels of hCG may also represent pregnancy with multiples, or an inaccurate measurement of gestational age (the pregnancy could be further along than expected).
What is a normal free beta-hCG level at 12 weeks?
Standard hCG levels
| Pregnancy week | Standard hCG range |
|---|---|
| 9–12 weeks | 25,700–288,000 mIU/mL |
| 13–16 weeks | 13,300–254,000 mIU/mL |
| 17–24 weeks | 4,060–165,400 mIU/mL |
| 25–40 weeks | 3,640–117,000 mIU/mL |
What is a positive beta-hCG test?
A positive beta hCG levels means that you are pregnant. The hCG level depends on how far along a woman is in her pregnancy. A positive beta human chorionic gonadotropin (hCG) level usually means that you are pregnant. Pregnancy tests detect the hCG hormone in the blood and urine.
What is the normal range for free beta hCG?
Understanding results ofBeta HCG Free and Total Serum
| Reference Range | Interpretation |
|---|---|
| <5.0 Miu/ml | Normal (non-pregnant) |
| <9.5 Miu/ml | Normal (postmenopausal) |
Does high hCG mean healthy pregnancy?
As with low levels, high levels of hCG do not necessarily indicate a problem with a pregnancy. Some women simply have higher levels. If a woman has high hCG levels, it could point to twins or triplets, though only a scan can confirm this. Sometimes, above-average levels of hCG indicate a higher chance of Down syndrome.
Does high hCG levels mean Down syndrome?
High values If you are pregnant, very high levels of hCG can mean a multiple pregnancy (such as twins or triplets). It can also mean a molar pregnancy or Down syndrome. You may also be further along in an early pregnancy than you thought, based on your last menstrual period.
What is Papp-A levels in pregnancy?
PAPP-A (Pregnancy associated plasma protein-A) is a protein produced by the placenta. It is needed for the implantation process and to maintain a healthy placenta (afterbirth). PAPP-A is a marker measured as part of the combined pregnancy screening blood test which is offered around 11-14 weeks of pregnancy.
When should a beta hCG test be done?
hCG is produced during pregnancy and found in the blood and urine. Testing for hCG can be used as soon as 10 days after conception to help determine if a person is pregnant.
Can low PAPP-A cause miscarriage?
Low levels of PAPP-A (when it is less than 0.4 MoM in pregnancy) may be associated with: A lower birth weight baby as your placenta may not work as well. An increased chance of having an early birth. Miscarriage in the second half of pregnancy.
What is the beta subunit of human chorionic gonadotropin?
hCG β-subunit is the only polypeptide known to be the root of multiple independent molecules like hCG, hyperglycosylated hCG, pituitary hCG and free β-subunit, hyperglycosylated hCG free β-subunit, and fetal hCG. From: Human Chorionic Gonadotropin (HGC) (Second Edition), 2015.
What is human chorionic gonadotropin (hCG)?
Human chorionic gonadotropin (hCG) is a 37-kD glycoprotein. hCG-β Subunit is synthesized by benign and malignant syncytiotrophoblasts. As a serum marker, β-hCG serves an important role in the diagnosis, staging, therapeutic monitoring, and follow-up of patients with gestational trophoblastic disease and NSGCT testicular tumors.
What is hCG β-core fragment?
Human chorionic gonadotropin β-core fragment (hCGβcf) is a polypeptide considered to be ubiquitously present in urine regardless of race, sex, and age. This fragment is mainly produced by the degradation of human chorionic gonadotropin in the kidney and excreted in the urine, representing around 80% of total hCG in urine.
What is the significance of the beta-hCG level in gestational trophoblastic disease?
The serum beta-hCG concentration is always elevated in gestational trophoblastic disease. hCG β-subunit is quite a remarkable molecule with an unusually flexible polypeptide and an extreme concentration of carbohydrate side chain consisting of 30% (hCG) to 42% (hyperglycosylated hCG) of the molecular weight.
