What is HLA-B 1502?
What is HLA-B 1502?
The HLA-B*1502 allele is highly associated with the outcome of carbamazepine-induced Stevens–Johnson syndrome and toxic epidermal necrolysis. This association has been found mostly in the Han Chinese, but not in Caucasian patients.
What is HLA b5701 test?
This test checks whether you have a certain gene that may predispose you (or make you more likely) to having an allergic reaction from one of the HIV medications (called abacavir). If you test positive for this gene, you should not be given abacavir.
What is HLA b* 15 02?
Purpose: HLA-B∗15:02 is strongly associated with life-threatening severe skin hypersensitivity reactions in patients treated with carbamazepine (CBZ) and structurally related medications. FDA-approved labeling recommends HLA-B∗15:02 screening before CBZ therapy in patients of Asian ancestry.
What haplotype is associated with carbamazepine response?
HLA-A*31:01 has been associated with carbamazepine-induced hypersensitivity reactions, particularly HSS, across different populations including European and Japanese individuals.
What is the HLA-B * 5701 allele?
Abacavir-induced hypersensitivity reaction has been associated with the presence of the major histocompatibility complex class I allele HLA-B*5701. A screening test for the HLA-B*5701 allele can assist clinicians to identify patients who are at risk of developing a hypersensitivity reaction to abacavir.
What is the HLA B * 5701 allele?
Introduction. The HLA allele B *5701 is strongly associated with hypersensitivity reactions to abacavir [1–4]. Hence, most treatment guidelines recommend that patients initiating abacavir be tested for the presence of this allele, and that those who are positive should not receive abacavir.
What is HLA a3101?
HLA-B*1502 and HLA-A*3101 are two alleles that have been associated with severe cutaneous adverse drug reactions (cADRs), including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), when taking certain mood stabilizers.
What are HLA A and HLA B?
HLA-A and HLA-B (major histocompatibility complex, class I, A, and B) are closely related proteins in the human leukocyte antigen (HLA) complex. They play major roles in the immune system and are found on nearly every cell.
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