What is hormone aromatization?

What is hormone aromatization?

Aromatization is the process of converting a nonaromatic ring into an aromatic ring and is catalyzed by aromatase, a P450 enzyme. Aromatization converts androgens into estrogens. Estrogens contain an aromatic six-carbon ring.

What is the precursor of estrogen and testosterone?

Estradiol, the most potent estrogen, is synthesized from testosterone. Estrone can be formed from estradiol, but its major precursor is androstenedione.

What is the aromatization hypothesis?

the hypothesis that, in some rodents, testicular androgens enter the brain and are converted there into estrogens by the action of the aromatase enzyme contained in neurons therein in order to masculinize the developing nervous system.

What hormone turns into testosterone?

Dihydrotestosterone is a hormone that stimulates the development of male characteristics (an androgen). It is made through conversion of the more commonly known androgen, testosterone.

Why does aromatization happen?

Aromatization mostly occurs when a large fluctuation of testosterone production occurs, such as when anabolic steroids are injected. The large amount of testosterone will be seen as an excess by the human body and aromatization will occur in an attempt to balance the new testosterone with a higher amount of estrogen.

What is the precursor of estrogen?

In short, androgens are precursors of estrogens; they are converted to estrogens through the action of an enzyme known as aromatase. The ovaries are the richest source of aromatase, although some aromatase is present in adipose tissue, which is also an important source of estrogen in postmenopausal women.

Is progesterone a precursor to testosterone?

The process through which our bodies turn fat into energy is also affected by progesterone, as well as thyroid hormone production. Since progesterone is a precursor to testosterone, low levels can often result in lack of sex drive, as conversely, it is an antagonist to estrogen.

Where is testosterone secreted?

Testosterone is produced by the gonads (by the Leydig cells in testes in men and by the ovaries in women), although small quantities are also produced by the adrenal glands in both sexes.

Which gland produces testosterone in males?

Testosterone is the main sex hormone found in men. It controls male physical features. The testes (testicles) make testosterone. Women have testosterone too but in much smaller amounts than in men.

What is aromatization of testosterone?

This natural process is known as aromatization and occurs at increased levels in aging males. It also occurs to a higher degree when testosterone is introduced exogenously, with increasing amounts of aromatization occurrence intrinsically linked to elevated levels of testosterone.

What is aromatization and how can it be controlled?

Aromatization results as a response to a spike in testosterone from Testosterone Replacement Therapy and this is controlled through the use of Aromatase Inhibitors (AI).

How is testosterone converted to estrogen?

In the human body, testosterone is converted into estradiol (a type of estrogen) by the enzyme aromatase. This natural process is known as aromatization and occurs at increased levels in aging males.

Can aromatase inhibitors help men with Estrogen dominance?

Men who experience problems from estrogen dominance have been using aromatase inhibitors to reduce some of the side effects, including fatigue, reduced sexual function, water retention, and depression.