What is IgA and its function?
What is IgA and its function?
Immunoglobulin A (IgA), as the principal antibody class in the secretions that bathe these mucosal surfaces, acts as an important first line of defence. IgA, also an important serum immunoglobulin, mediates a variety of protective functions through interaction with specific receptors and immune mediators.
What causes high IgA levels?
Causes of increased IgA levels include: chronic infections. chronic liver disease. rheumatoid arthritis with high titres of rheumatoid factor. SLE (occurs in some patients)
What is total IgA?
Total serum IgA: This test is used to check for IgA deficiency, a condition associated with celiac disease that can cause a false negative tTG-IgA or EMA result. If you are IgA deficient, your doctor can order a DGP or tTG-IgG test.
What are normal IgA and IgG levels?
Normal Ranges Adult: IgG 6.0 – 16.0g/L. IgA 0.8 – 3.0g/L.
Is High IgA always bad?
Takeaway. High IgA usually points to chronic infections or inflammation, though diverse disorders can raise its levels. In adults, values above 300 mg/dL are considered high by most labs. High levels do not cause any symptoms.
Can high IgA be normal?
High IgA (above normal range) Elevated IgA levels are nonspecific, but can be seen in pulmonary and gastrointestinal inflammatory diseases, some autoimmune conditions, liver disease, and plasma cell disorders.
What is IgG function?
IgG is the main type of antibody found in blood and extracellular fluid, allowing it to control infection of body tissues. By binding many kinds of pathogens such as viruses, bacteria, and fungi, IgG protects the body from infection.
What does IgA bind to?
Polymeric IgA (illustrated here as an IgA dimer) secreted by lamina propria plasma cells binds to pIgR on the basolateral surface of epithelial cells and is transcytosed to the apical surface. IgA-bound and unoccupied pIgR are transcytosed through epithelial cells along with unoccupied pIgR.
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