What is intranasal administration?
What is intranasal administration?
Nasal administration, popularly known as snorting, is a route of administration in which drugs are insufflated through the nose. It can be a form of either topical administration or systemic administration, as the drugs thus locally delivered can go on to have either purely local or systemic effects.
How is intranasal medications administered?
They are sprayed into the nostrils, usually to produce a local effect directly inside the nose. Some nasal sprays are used to administer medicine that acts on other parts of the body. In these cases the medicine is taken into the bloodstream from the lining of the nose, which has many blood vessels.
Which of the following is a disadvantage of nasal systemic delivery?
Anatomical and physiological factors affecting intranasal systemic delivery
| Advantages | Disadvantages |
|---|---|
| Large surface area for absorption (approximately 160 cm2) | Limited to small delivery volumes (25–200 µL) therefore require potent drugs |
| Good blood supply and lymphatic system | Mucociliary clearance, mucus barrier |
Why is intranasal used?
Intranasal drug administration has a long tradition and was and is still used for medical as well as recreational purposes. The most common use is for treatment of local symptoms e.g. nasal congestion in the course of a common rhinitis or inflammation linked to allergic rhinitis.
What are the advantages of nasal spray?
Helps to wash out viruses, allergens and irritants in the nose. Helps cleanses and hydrate nasal tissues which is important for the maintenance of nasal immunity. Can improve the effectiveness of medicated nasal sprays when the nasal saline is used first.
What does intranasal use only mean?
Medical Definition of intranasal : lying within or administered by way of the nasal structures.
How does intranasal oxytocin work?
Current thinking on how intranasal oxytocin exerts its effects. A key assumption of intranasal administration is that it provides direct access to the brain as it bypasses the blood brain barrier, which prevents transport of larger-sized molecules (like oxytocin) circulating in blood from crossing this barrier.
What is the difference between intranasal and inhalation?
Intranasal instillation of virus in a liquid suspension (IN) is the most frequently employed method to inoculate small mammalian models with influenza virus, but does not reflect a natural route of exposure. In contrast, inoculation via aerosol inhalation (AR) more closely resembles human exposure to influenza virus.
Is intranasal a parenteral route?
For small therapeutic molecules, various routes for drug administration are parenteral (intravenous, intramuscular, and subcutaneous), oral, nasal, ocular, transmucosal (buccal, vaginal, and rectal), and transdermal.
