What is lidocaine base?
What is lidocaine base?
Product description. Lidocaine is a local anesthetic used to prevent and treat pain, for example, during surgical or diagnostic procedures. It is also used for the treatment of cardiac arrhythmias. Lidocaine can be administered orally, in topical applications or as a solution for injection.
Why is lidocaine mixed with HCl?
This pH is so far below the drug’s pKa that essentially all the drug is present in the more stable, charged, water-soluble form. Hydrochloric acid is added to lignocaine solutions to achieve this low pH.
Is lidocaine HCl water soluble?
Solubility : Soluble in water (50 mg/ml), chloroform, ethanol, and benzene. Insoluble in diethyl ether.
What is the pH of lidocaine?
Plain 1% lidocaine had a pH of 6.09±0.16, and plain 2% lidocaine had a pH of 6.00±0.27.
Is lidocaine polar or non polar?
At that pH, there are two species of lidocaine molecules: one is the charged or polar molecule, and the other is the uncharged or nonpolar molecule. There is a predominance of the charged molecule: about 10 times as much charged/polar lidocaine ion as uncharged/nonpolar lidocaine.
Why is lidocaine soluble in water?
Lidocaine is an Anesthetic (local); antiarrhythmic (class IB). Long-acting, membrane stabilizing agent against ventricular arrhythmia. Originally developed as a local anesthetic….137-58-6.
| Melting point | 66-69°C |
|---|---|
| Water Solubility | practically insoluble |
| Merck | 14,5482 |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
Is lidocaine an HCL?
Lidocaine Hcl is used to numb an area of your body to help reduce pain or discomfort caused by invasive medical procedures such as surgery, needle punctures, or insertion of a catheter or breathing tube. Lidocaine Hcl is a generic drug, popular brand-name versions include UAD Caine, Xylocaine HCl, and Xylocaine-MPF.
How do you use lidocaine HCL?
Use lidocaine exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor. For a sore or irritated mouth, the dose should be placed in the mouth, swished around until the pain goes away, and spit out. For a sore throat, the dose should be gargled and then may be swallowed.
Is lidocaine hydrophilic or hydrophobic?
As a tertiary amine, lidocaine can be hydrophilic when it is protonated and can be hydrophobic when it is in its neutral form.
Is lidocaine an acid?
Lidocaine with epinephrine is very acidic compared with subcutaneous tissue. The addition of 8.4% bicarbonate at a volume ratio of 1 mL:10 mL neutralizes the acidity of 1% lidocaine with 1:100,000 epinephrine. Neutralizing the pH of lidocaine has been previously shown to decrease the pain of injection.
Are local Anaesthetics acidic?
Most local anaesthetics are weak bases, with a pKa between 8 and 9, so that they are mainly but not completely ionised at physiological pH. The un-charged species (B) penetrates the nerve sheath and axonal membrane and is then converted to the BH+ active form, which then blocks the Na+ channels.
Is lidocaine neutral?
The lidocaine base is weakly basic and tends to combine with acids to form salts.
What are the strengths of lidocaine?
Common strengths are 1%, 2% and 4%. One percent lidocaine means that there is one gram of lidocaine in one hundred milliliters of liquid solution. In addition to being a very useful topical anesthetic, lidocaine also serves as a cardiac anti arrhythmic.
Is lidocaine a generic drug?
Lidocaine (Lidoderm, Xylocaine) is an inexpensive drug used to prevent and treat pain from some procedures. This drug is more popular than comparable drugs. It is available in multiple generic and brand versions. Generic lidocaine is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
What is the chemical formula for lidocaine?
Lidocaine Description. Lidocaine HCl (C 14 H 22 N 2 O • HCl) has the following structural formula: Lidocaine HCl Injection, USP solution is for single dose usage, and is M ethyl P araben F ree (Preservative-Free).
What is the structural formula for lidocaine?
Lidocaine HCl (C14H22N2O • HCl) has the following structural formula: Lidocaine HCl Injection, USP solution is for single dose usage, and is Methyl Paraben Free (Preservative-Free). Lidocaine HCl Injection, USP is a sterile, nonpyrogenic, isotonic solution containing sodium chloride.
