What is myogenic differentiation?

What is myogenic differentiation?

Myogenic differentiation proceeds through irreversible cell cycle arrest of precursor cells (myoblasts), followed by a gradual increase in expression of muscle function genes, leading to fusion of myoblasts into multinucleate myofibers in the animal.

How does a niche control stem cell differentiation?

During embryonic development, various niche factors act on embryonic stem cells to alter gene expression, and induce their proliferation or differentiation for the development of the fetus. The stem cells and niche may induce each other during development and reciprocally signal to maintain each other during adulthood.

What is the role of Myogenin in Myogenesis?

Myogenin (also known as Myf4) is required for the fusion of myogenic precursor cells to either new or previously existing fibers. In general, myogenin is associated with amplifying expression of genes that are already being expressed in the organism.

What is myogenic theory?

The myogenic theory of autoregulation states that an intrinsic property of the blood vessel, or more specifically, vascular smooth muscle, regulates vascular tone in response to changes in intraluminal pressure.

What is the function of myoblast?

Myoblast fusion contributes to muscle growth in development and during regeneration of mature muscle. Myoblasts fuse to each other as well as to multinucleate myotubes to enlarge the myofiber. The molecular mechanisms of myoblast fusion are incompletely understood.

What is the ability of stem cells to differentiate into a diverse number of mature cell types called?

The ability of a differentiated stem cell of one lineage to produce cells of a different lineage is called transdifferentiation.

What is the importance of the differentiation of stem cells within an animal?

Stem cells function as a source of new cells to grow or replace specialised tissues. To perform this function, these cells must divide to renew themselves, while some of their descendants eventually differentiate to build up new tissues.

What is meant by cell differentiation brief on Myogenesis?

Cell differentiation describes the process of specialization leading to the formation of brain, heart, and all other tissues from the single-cell zygote and the primitive, three-layered embryo.

Are Myotube and Myofiber the same?

As nouns the difference between myofiber and myotube is that myofiber is muscle fiber while myotube is (anatomy) a structure of elongated multinucleate cells that contains some peripherally located myofibrils.

How is myogenic tone calculated?

The level of myogenic tone developed at a given intraluminal pressure was calculated according to the following equation: myogenic tone=100×[(dCa-free−d)/(dCa-free−dKPSS)] where dCa-free is the diameter obtained at a given luminal pressure in Ca2+-free solution, d is the steady state diameter reached by the vessel at a …

What is the role of myogenic autoregulation?

What is a myoblast definition?

Definition of myoblast : an undifferentiated cell capable of giving rise to muscle cells.

How do you induce myogenic differentiation in amniotic fluid?

Myogenic differentiation is induced in amniotic fluid-derived progenitor cells by culture in medium containing horse serum and chick embryo extract on a thin gel coat of Matrigel (Rosenblatt et al., 1995). To initiate differentiation, the presence of 5-azacytidine in the medium for 24 h is necessary.

What is myogenesis in biology?

Myogenesis is an ordered process whereby mononuclear MPCs exit the cell cycle, differentiate, and fuse either with existing myofibers or with each other to form new myofibers [187].

What are the stages of myoblast differentiation?

Myoblast differentiation proceeds in stages. The first stage, involves cell cycle exit and the commencement of expression of certain genes. The second stage of differentiation involves the alignment of the myoblasts with one another.

What is the regulatory pathway for myogenic differentiation?

Regulation of myogenic differentiation is controlled by two pathways: the phosphatidylinositol 3-kinase /Akt pathway and the Notch /Hes pathway, which work in a collaborative manner to suppress MyoD transcription.