What is Neoral used to treat?
What is Neoral used to treat?
Cyclosporine is used to prevent organ rejection in people who have received a liver, kidney, or heart transplant. It is usually taken along with other medications to allow your new organ to function normally. Cyclosporine is also used to treat severe cases of rheumatoid arthritis and plaque psoriasis.
How is cyclosporine metabolized?
Cyclosporine and tacrolimus are metabolized primarily by cytochrome P450 3A4 (CYP3A4) in the liver and small intestine. There is also evidence that cyclosporine is metabolized to a lesser extent by cytochrome P450 3A5 (CYP3A5).
What is cyclosporine used for?
Cyclosporine is used together with other medicines to prevent the body from rejecting a transplanted organ (eg, kidney, liver, or heart). It belongs to a group of medicines known as immunosuppressive agents.
What is cyclosporine mechanism of action?
Cyclosporine is a potent immunomodulatory agent with an increasing number of clinical applications. Its major mode of action is inhibition of the production of cytokines involved in the regulation of T-cell activation. In particular, cyclosporine inhibits the transcription of interleukin 2.
What are the side effects of Neoral?
Common side effects of cyclosporine include:
- High blood pressure.
- Increased hair growth.
- Swollen or inflamed gums.
- Numbness or tingling of the hands or feet.
- Other common side effects are tremors, restlessness, stomach upset, nausea, cramps, diarrhea, headache, and changes in blood sugar.
What kind of drug is Neoral?
Neoral (cyclosporine) is an immunosuppressant used to prevent organ rejection after a kidney, liver, or heart transplant. Neoral is also used to treat severe psoriasis or severe rheumatoid arthritis. Neoral is available in generic form.
Is cyclosporine absorbed orally?
Absorption is probably improved by thorough dispersion of the oral solution of CsA in the drink the patient prefers. Evidence for GI metabolism of CsA has only been gathered in animal experiments. The importance of bile for absorption of CsA into the portal blood is established.
Is cyclosporine A biologic?
Cyclosporine and methotrexate are two non-biological systemic treatments for psoriasis (see also the overview on systemic treatments). Both medicines work in different ways by slowing down the skin cell production and reducing inflammation. They are usually taken as tablets, but can also be given as injections.
What are side effects of cyclosporine?
Is cyclosporine an anti inflammatory?
Introduction: It is well known that cyclosporin A (CsA) exhibits important anti-inflammatory effects, besides its immunosuppressive activity.
Is ciclosporin a biologic?
Is cyclosporine A chemotherapy?
RATIONALE: Some cancers become resistant to chemotherapy drugs. Combining cyclosporine with chemotherapy may prevent resistance to the drugs and allow the cancer cells to be killed….
| Condition or disease | Intervention/treatment | Phase |
|---|---|---|
| Leukemia | Drug: cyclosporine Drug: etoposide Drug: mitoxantrone hydrochloride | Phase 2 |
What is cyclosporine prescribed for?
Cyclosporine is the generic name of the prescription eye drop Restasis, used to treat dry eyes caused by an inability to produce enough natural tear fluid.
Is cyclosporine an antibiotic?
Cyclosporine is used to prevent organ rejection in people who have received a liver, kidney, or heart transplant. It is usually taken along with other medications to allow your new organ to function normally. Cyclosporine belongs to a class of drugs known as immunosuppressants. It works by weakening the immune system to help your body…
