What is P2Y2 receptor?
What is P2Y2 receptor?
As one of G-protein-coupled receptors, P2Y2 receptor can transactivate EGFR and increase mitogen-activated protein kinase and phosphoinositide 3-kinase activity in many cancer cells (Soltoff, 1998; Muscella et al, 2003). P2Y2 receptor exerts contrasting effects on cell proliferation of different cancers.
Where are P2Y receptors found?
Pharmacology of Purine and Pyrimidine Receptors P2Y receptors are expressed in both neurons and glial cell types in the CNS (Abbracchio et al., 2009; Fischer & Krügel, 2007).
What happens during G-protein coupled receptor?
aka metabotropic receptor or GPCR. When a ligand binds to these membrane-bound receptor proteins, the receptor activates intermediate proteins called G-proteins. These G-proteins can then activate enzymes, open ion channels, and initiate intracellular signaling cascades.
What is the role of GTP in G-protein-coupled receptors?
When a ligand activates the G protein-coupled receptor, it induces a conformational change in the receptor that allows the receptor to function as a guanine nucleotide exchange factor (GEF) that exchanges GDP for GTP. The GTP (or GDP) is bound to the Gα subunit in the traditional view of heterotrimeric GPCR activation.
Is clopidogrel an anticoagulant drug?
Some common antiplatelet drugs are aspirin, dipyridamole and clopidogrel. Anticoagulants Anticoagulants also stop your blood from being able to clot as easily. They do this by stopping your blood from producing certain proteins, which platelets need to help them form a clot.
What keeps platelets from sticking together?
Antiplatelet drugs, such as aspirin, prevent blood cells called platelets from clumping together to form a clot. When you take a blood thinner, follow directions carefully. Blood thinners may interact with certain foods, medicines, vitamins, and alcohol.
What is a P2Y2 inhibitor?
Nucleotides are important extracellular signaling molecules that mediate several events, such as cell proliferation, differentiation, chemotaxis and cytokine release. Biochemicals that inhibit P2Y2 have many applications in biochemical and physiological research.
Are G proteins trimeric or monomeric GTPases?
G proteins are of two types- Monomeric and Trimeric G proteins respectively. Extracellular signalling molecules that bind to Enzyme-linked receptors are converted by monomeric G-proteins. Extracellular signalling molecules that bind to G-protein linked receptors are converted by trimeric G-proteins.
