What is perineural disease?
What is perineural disease?
Abstract. Perineural involvement is a well-recognized clinicopathologic entity found in head and neck (H&N) cancers, including mucosal epithelial carcinomas and salivary gland malignancies. Perineural disease remains a diagnostic, prognostic and therapeutic challenge for the multidisciplinary H&N oncology team.
What is the meaning of perineural?
Medical Definition of perineural : occurring about or surrounding nervous tissue or a nerve.
Does perineural invasion mean metastasis?
Perineural invasion (PNI) can be found in a variety of malignant tumors. It is a sign of tumor metastasis and invasion and portends the poor prognosis of patients. The pathological description and clinical significance of PNI are clearly understood, but exploration of the underlying molecular mechanism is ongoing.
How common is perineural invasion?
Results. The prevalence of PNI was 7% and 44% in the untreated and treated cohorts, respectively. PNI was more common in high Gleason grade tumors in both cohorts.
What are the symptoms of perineural tumor spread along auriculotemporal nerve?
More than 50% of patients with perineural tumor spread along the auriculotemporal nerve had clinical signs of auriculotemporal nerve dysfunction, including periauricular pain and temporomandibular joint (TMJ) dysfunction or tenderness. Images in 13 of 15 patients with such tumor spread demonstrated findings of tumor growth along V 3..
What is perineural tumour spread (PNTs)?
Perineural tumour spread (PNTS) in head and neck oncology is most often caused by squamous cell carcinoma. The most frequently affected nerves are the trigeminal and facial nerves. Up to 40% of patients with PNTS may be asymptomatic.
What are the signs and symptoms of auriculotemporal nerve entrapment?
Periauricular pain, TMJ dysfunction or tenderness, and imaging signs of V 3 involvement are important indicators of potential involvement of the auriculotemporal nerve. Infiltrating carcinomas of the head and neck region may disseminate along nerves and lead to a circumstance that may create a poor prognosis and require aggressive treatment ( 1 ).
What causes perineural perineural spread along the maxillary nerve?
Perineural spread along the maxillary nerve may occur with cutaneous tumours arising from the facial region innervated by its peripheral branches, and oropharyngeal or sinonasal neoplasms.
