What is reproductive toxicology studies?
What is reproductive toxicology studies?
Reproductive toxicology is the study of the effects of chemicals on the reproductive and neuroendocrine systems, and also the embryo, fetus, neonate and prepubertal mammal.
Which is an example of reproductive toxin?
Reproductive toxins include physical agents (e.g. radiation), biological agents (e.g. viruses), maternal metabolic imbalances, and chemical agents. It is listed in Appendix V(j)-A as an “Example of Known or Suspected Human Reproductive Toxins”.
What is the difference between developmental toxicity and reproductive toxicity?
Reproductive toxicity is defined as adverse effects of a chemical substance on sexual function and fertility in adult males and females, as well as developmental toxicity in the offspring. Developmental toxicity pertains to adverse toxic effects to the developing embryo or fetus.
What are affected during reproduction toxicology?
Reproductive toxicity is a hazard associated with some chemical substances, which interfere in some way with normal reproduction; such substances are called reprotoxic. They may adversely affect sexual function and fertility in adult males and females, as well as causing developmental toxicity in the offspring.
Why is Occupational Toxicology important?
The objective of the occupational toxicologist is to prevent adverse health effects in workers that result from their work environment. Because the work environment often presents exposures to complex mixtures, the occupational toxicologist must also recognize exposure combinations that are particularly hazardous.
How do you test for reproductive toxicity?
Long considered the definitive test of reproductive toxicity is the two-generation reproduction toxicity study (OECD TG 416), which involves continuous dosing of parental rats and their offspring with the test substance (usually in the diet, but other routes are possible) for two entire generations, up through weaning …
What is reproductive damage?
Reproductive Harm occurs when a chemical interferes with the ability to produce normal, healthy offspring. This includes effects on the female and male reproductive systems, and effects on the developing embryo, fetus, or child, resulting from exposure during pregnancy.
What are the 4 major outcomes considered in developmental toxicity?
The major manifestations of developmental toxicity include: (1) death of the developing organism, (2) structural abnormality, (3) altered growth, and (4) functional deficiency. Altered growth – An alteration in offspring organ or body weight or size.
Why is occupational Toxicology important?
What are occupational toxins?
From Wikipedia, the free encyclopedia. Occupational toxicology is the application of toxicology to chemical hazards in the workplace.
Who is reproductive toxicology written for?
Drawing from a large number of disciplines, Reproductive Toxicology publishes timely, original research on the influence of chemical and physical agents on reproduction. Written by and for obstetricians, pediatricians, embryologists, teratologists, geneticists, toxicologists, andrologists, and …
What is an example of reproductive toxicity?
Reproductive toxicity. However, many substances which are toxic for reproduction do not fall into either of these groups: lead compounds, for example, are considered to be toxic for reproduction given their adverse effects on the normal intellectual and psychomotor development of human babies and children.
What isreproductive toxicology?
Reproductive toxicology is the subject area dealing with the causes, mechanisms, effects and prevention of disturbances throughout the entire reproductive cycle, including fertility induced by chemicals.
What does reprotoxic mean in chemistry?
The international pictogram for chemicals that are sensitising, mutagenic, carcinogenic or toxic to reproduction. Reproductive toxicity is a hazard associated with some chemical substances, which interfere in some way with normal reproduction; such substances are called reprotoxic.
