What is S6K1 (S6K1)?
What is S6K1 (S6K1)?
The p70/p85 S6 kinase 1 (S6K1), which is able to catalyze the phosphorylation of rpS6 at all sites, was the first kinase identified ( Krieg et al., 1988; Ferrari et al., 1991; Bandi et al., 1993; Meyuhas, 2008, 2015 ). Further studies described additional protein kinases targeting selectively the Ser235 and Ser236 residues.
What is the role of p90 ribosomal s6 kinase 1 (RSK1)?
PKA is also activated by a protein–protein interaction between Prkar1a and p90 ribosomal S6 kinase 1 (RSK1), a kinase that plays fundamental roles in regulating a variety of biological processes, including cell proliferation and inhibition of apoptosis, downstream of the extracellular signal-regulated protein kinase 1/2 (Erk1/2; Gao et al., 2010 ).
What is the function of S6 kinase?
In molecular biology, ribosomal s6 kinase (rsk) is a family of protein kinases involved in signal transduction. There are two subfamilies of rsk, p90 rsk, also known as MAPK-activated protein kinase-1 (MAPKAP-K1), and p70 rsk, also known as S6-H1 Kinase or simply S6 Kinase.
What is the TOS motif in S6K1?
S6K contains a TOR signaling (TOS) motif in the N-terminus, a conserved five amino acid sequence found in mTORC1 substrates and is crucial for mTOR regulation [25]. Truncation of the N-terminus including the TOS motif prevents kinase activation of S6K1. The kinase domain is followed by the linker domain that includes the TM and HM.
