What is SCL 70 normal range?
What is SCL 70 normal range?
The upper limit of normal for the Test-Scl-70 ELISA was established with 50 randomly chosen BBD sera by the percentile ranking method (28) at 32 units/ml, for a disease specificity of 100% (28) (the mean + 3SD was 26 units/ml).
Can SCL 70 be a false positive?
Scl-70 (topo-1) is a DNA binding protein and anti-DNA/DNA complexes in the sera of SLE patients may bind to topo-I, leading to a false-positive result. The presence of Scl-70 antibody in sera may also be due to contamination of recombinant Scl-70 with DNA derived from cellular material used in immunoassays.
Can you have a positive SCL 70 and not have scleroderma?
Serum anti-topoisomerase, also known as SCL-70, is specific to diffuse scleroderma (and the test is positive in 20% of people with scleroderma). Two-thirds of patients with this antibody have diffuse scleroderma.
Does everyone have SCL-70 antibodies?
Anti-Scl-70 antibodies are found in about 40% of patients with diffuse cutaneous systemic sclerosis (dcSSc) and less than 10% of patients with limited cutaneous systemic sclerosis (lcSSc) [35, 36].
Can you have a positive SCL-70 and not have scleroderma?
What is a SCL 70 antibody?
Scl 70 (topoisomerase 1) is a 100-kD nuclear and nucleolar enzyme. Scl 70 antibodies are considered to be specific for scleroderma (systemic sclerosis) and are found in up to 60% of patients with this connective tissue disease.
What is an anti-ENA screen?
An anti-ENA screen determines the levels of seven different autoantibodies including anti-Sm, anti-RNP, anti-SSA, anti-SSB, anti-Jo-1, anti-Scl 70 and anti-CENP-B. Each antibody (or combination of antibodies) is specific to a different collagen disease.
What does a negative Scl-70 and ACA test mean?
When the symptoms of scleroderma are present, the SCL-70 test is negative, but the ACA blood test is positive, then a different autoimmune disorder may be affecting the body. Lupus is the most common issue associated with this set of test results, but primary biliary cirrhosis or rheumatoid arthritis may also be present.
How accurate is the SCL-70 blood test for scleroderma?
Unlike other blood tests that can generate false positives, the SCL-70 blood test is very accurate when it comes to a positive result. The antibodies are very specific to scleroderma and are very rarely present with other diseases or disorders.
