What is sodium starch glycolate used for?
What is sodium starch glycolate used for?
Sodium starch glycolate is a commonly used super-disintegrant employed to promote rapid disintegration and dissolution of IR solid dosage forms. It is manufactured by chemical modification of starch, i.e., carboxymethylation to enhance hydrophilicity and cross-linking to reduce solubility.
Why is sodium starch glycolate an indicator instead of starch?
Sodium starch glycolate is the sodium salt of carboxymethyl ether. Sodium starch glycolate absorbs water rapidly, resulting in swelling which leads to rapid disintegration of tablets and granules.
What is sodium starch glycolate type B?
» Sodium Starch Glycolate is the sodium salt of a carboxymethyl ether of starch or of a crosslinked carboxymethyl ether of starch. It may contain not more than 7.0 percent of Sodium Chloride. The pH and assay requirements for Type A and Type B are set forth in the accompanying table.
Is sodium starch glycolate soluble in water?
It is practically insoluble in water and also in most organic solvents. This product is used as a pharmaceutical-grade dissolution agent and super disintegrant which is produced from corn or potato starch. Sodium Starch Glycolate is spherical granules that absorbs water rapidly and swell up.
What is glycolate type A?
Sodium starch glycolate type A potato is the sodium salt of carboxymethyl ether of starch from potato origin. Starch glycolates are also of rice, wheat or corn origin. It is a white to off-white, tasteless, odorless, relatively free-flowing powder.
What is sodium starch glycolate type A?
What is it? Sodium starch glycolate type A potato is the sodium salt of carboxymethyl ether of starch from potato origin. Starch glycolates are also of rice, wheat or corn origin. It is a white to off-white, tasteless, odorless, relatively free-flowing powder.
How do you make sodium starch glycolate?
Sodium glycolate Solution (B): Dissolve 0.310 g of glycollic acid, previously dried in vacuum over diphosphorus pentoxide, in water and dilute to 500.0 ml with the same solvent.
What is difference between sodium starch glycolate type A and type B?
SSG Type A and SSG Type B are cross-linked salts of sodium, which is partly O-carboxymethylated potato starch. Whereas, SSG type C is formed as a result of cross linking of sodium salt of partly carboxymethylated starch, by physical dehydration.
How do you dissolve sodium starch glycolate?
Sodium glycolate Solution (A): In a 250 ml clean & dry conical flask take 0.2 g. of the sample, add 5 ml of glacial acetic acid, mix well and add 5 ml of water, continue stirring until complete dissolution.
Is sodium starch glycolate organic or inorganic?
Sodium glycolate is an organic sodium salt comprising equal numbers of sodium and glycolate ions. It has a role as a keratolytic drug.
What is sodium starch glycolate made of?
potato starch
Sodium starch glycolate is the sodium salt of carboxymethyl ether. It is white to off-white, odorless, tasteless, and free-flowing powder. It is produced by cross-linking and carboxy methylation of potato starch. It can also be manufactured from other starch foods such as corn, wheat, and rice.
How do you make a sodium glycolate solution?
8. Sodium glycolate Solution (A): In a 250 ml clean & dry conical flask take 0.2 g. of the sample, add 5 ml of glacial acetic acid, mix well and add 5 ml of water, continue stirring until complete dissolution.
How to prepare IR absorption spectrum of sodium starch glycolate?
A. The IR absorption spectrum of the sample is concordant with the reference spectrum or with the spectrum obtained from sodium starch glycolate WRS. Procedure: Dissolve 2 g sample and disperse in 100 ml of water. Take 5 ml of above dispersion and add 0.05 ml 0.005M iodine. A dark blue color is produced.
What is thededefinition result of sodium starch glycolate?
DEFINITION Result = 100 × (22.99) × V × N/W. Sodium Starch Glycolate is the sodium salt of a carboxy- methyl ether of starch or of a cross-linked carboxymethyl V = volume of perchloric acid consumed (mL) ether of starch.
How to prepare sodium chloride from silver nitrate solution?
Take 10.0 ml of this solution in a 250 ml conical flask; add 30 ml of water and 5 ml of dilute nitric acid. Titrate with 0.1M silver nitrate determining the endpoint potentiometrically, using a silver indicator electrode. 1 ml of 0.1M silver nitrate is equivalent to 5.844 mg of NaCl, calculate sodium chloride content using following formula.
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