What is splenic autotransplantation?

What is splenic autotransplantation?

Definition. As outlined above, splenic autotransplantation is the implantation of a portion of the excised spleen, generally to a heterotopic location in the peritoneal cavity. It has most commonly been applied therapeutically in the trauma setting.

What is splenic tissue?

The spleen is the largest lymphatic organ in the body. Surrounded by a connective tissue capsule, which extends inward to divide the organ into lobules, the spleen consists of two types of tissue called white pulp and red pulp.

Can spleen be transplanted?

Conclusions: Allograft spleen can be transplanted within a multivisceral graft without significantly increasing the risk of GVHD. The allogenic spleen seems to show a protective effect on small bowel rejection.

Is the spleen regenerative?

Spleen is an organ with the innate capacity to regenerate. Spontaneous tissue regeneration can be observed after cases of splenic trauma, when fragments of ruptured spleen tissue spill into the abdominal cavity and seed the formation of small, spleen-like nodules.

Should splenic autotransplantation be considered after total splenectomy due to trauma?

We found that the adjusted risk of death in splenectomized patients is greater than that of the general population, and when total splenectomy is performed, splenic autotransplantation is the only method capable of preserving splenic function, avoiding infections, especially postsplenectomy sepsis.

What causes Splenosis?

Splenosis is the result of spleen tissue breaking off the main organ and implanting at another site inside the body. This is called heterotopic autotransplantation of the spleen. It most commonly occurs as a result of traumatic splenic rupture or abdominal surgery.

What is the structure and function of the spleen?

The spleen sits in the upper left of the abdomen, protected by the rib cage. It is the largest organ of the lymphatic system — the circulation of the immune system. It recycles old red blood cells and stores platelets (components of the blood that help stop bleeding) and white blood cells.

What are the structures at the hilum of spleen?

Splenic hilum, on the surface of the spleen, admits the splenic artery, vein, lymph vessels, and nerves. Hilum of lung, a triangular depression where the structures which form the root of the lung enter and leave the viscus. Hilum of lymph node, the portion of a lymph node where the efferent vessels exit.

Can a person live a normal life without a spleen?

You can live without a spleen. But because the spleen plays a crucial role in the body’s ability to fight off bacteria, living without the organ makes you more likely to develop infections, especially dangerous ones such as Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae.

Is spleen removal major surgery?

Removing your spleen is a major surgery and leaves you with a compromised immune system. For these reasons, it’s only performed when truly necessary. The benefits of a splenectomy are that it can resolve several health issues such as blood diseases, cancer, and infection that could not be treated any other way.

How spleen is formed?

The spleen is unique in respect to its development within the gut. While most of the gut organs are endodermally derived, the spleen is derived from mesenchymal tissue. Specifically, the spleen forms within, and from, the dorsal mesentery.

What is spleen function?

The spleen has some important functions: it fights invading germs in the blood (the spleen contains infection-fighting white blood cells) it controls the level of blood cells (white blood cells, red blood cells and platelets) it filters the blood and removes any old or damaged red blood cells.