What is sulfone in chemistry?

What is sulfone in chemistry?

A sulfone is a chemical compound containing a sulfonyl functional group attached to two carbon atoms. The central hexavalent sulfur atom is double-bonded to each of two oxygen atoms and has a single bond to each of two carbon atoms, usually in two separate hydrocarbon substituents.

Is sulfone a good leaving group?

Sulfones with a good leaving group in the β position may undergo reductive elimination under desulfonylation conditions to afford alkenes. This process is a key step of the Julia olefination, which yields alkenes via addition of an α-sulfonyl carbanion to an aldehyde followed by reductive elimination.

Is sulfoxide chiral?

Sulfoxides are conformationally stable at room temperature and therefore can be separated into pure enantiomers. Sulfoxides are found in a variety of natural products. They have also been employed as chiral auxiliaries in a range of reaction classes, and more recently as chiral ligands.

Is sulfone related to sulfa?

A sulfone is an 0=S=0 group connected to two R groups. A sulfonamide is created when one of the R groups is an amide (NH2). Sulfonamides are also called sulfa drugs.

Is sulfone a sulfur?

sulfone, also spelled Sulphone, any of a family of organic sulfur compounds in which two carbon-containing combining groups are linked to the group SO2. The best known members of the family are the polysulfone (q.v.) resins and several drugs used in the treatment of leprosy.

Is sulfone electron withdrawing group?

Properties of sulfonamides Carbonyl compounds, sulfones, sulfonate esters and sulfon- amides all exert an electron-withdrawing effect on surround- ing atoms both mesomerically and inductively. The effect of the sulfonamide is, however, the least electron-withdrawing component of all of these groups.

Is sulfone chiral?

Chiral sulfones, especially those compounds whose sulfone groups are directly connected to the chiral centers, are privileged building blocks in many natural products and bioactive compounds. Thus, the development of novel and efficient methods for the synthesis of these chiral sulfones becomes more important.

What is sulfone therapy?

The sulfones, which are bacteriostatic, are used principally for the treatment of leprosy. They are useful for the treatment of a variety of dermatologic disorders, such as dermatitis herpetiformis. Effectiveness in this condition may be due primarily to its anti-inflammatory, rather than antibacterial, effect.

What is a sulfone functional group?

Sulfone: A functional group characterized by a sulfur atom doubly-bonded to two oxygen atoms, and flanked by two carbon atoms of any hybridization.