What is terfenadine used for?
What is terfenadine used for?
Terfenadine, a bioprecursor prodrug, is an antihistamine used for the treatment of allergic conditions. It is completely metabolized in the liver by the enzyme cytochrome P450 3A4 isoform to give the active metabolite fexofenadine (Figure 28.43) [147].
Why was terfenadine removed from the market?
Terfenadine was taken off the market due to the risk of cardiac arrhythmia caused by QT prolongation. The active metabolite is not cardiotoxic, however, and is now sold under the brand name Allegra.
What is terfenadine and astemizole?
Abstract. Concurrent use of terfenadine or astemizole with erythromycin or ketoconazole can prolong the QT interval and produce potentially fatal ventricular arrhythmias. We examine the frequency and patterns of concurrent prescribing and suggest methods to reduce the incidence of serious drug interactions.
What type of drug is terfenadine?
Terfenadine is an antihistamine. Antihistamines prevent sneezing, runny nose, itching and watering of the eyes, and other allergic symptoms. Terfenadine is used to treat allergies, hives (urticaria), and other allergic inflammatory conditions.
What is difference between fexofenadine and terfenadine?
Results: Fexofenadine was as potent as terfenadine in limiting pruritus and nasal congestion. Rhinorrhea and sneezing were better controlled by fexofenadine than by terfenadine. Overall, the allergen concentration necessary to reach the combined reaction threshold was increased after treatment with both drugs.
Are terfenadine and fexofenadine the same?
(1) Fexofenadine, a non anticholinergic non sedative antihistamine, is available in France for oral treatment of allergic rhinitis and chronic urticaria. (2) Fexofenadine is actually an active metabolite of terfenadine, a drug taken off the market because of its cardiotoxicity.
Is terfenadine the same as fexofenadine?
Is terfenadine an antihistamine?
Terfenadine is an antihistamine recently approved for use in the U.S. Terfenadine possesses a unique chemical structure when compared with other antihistamines. It is a selective inhibitor of H1-receptors with little or no anticholinergic, antiserotoninergic, or antiadrenergic effects.
