What is the clozapine registry?
What is the clozapine registry?
The Clozapine REMS ensures appropriate patient monitoring for and management of clozapine-induced severe neutropenia and provides a centralized system for prescribers and pharmacists in managing patient risk, regardless of which clozapine product is being used.
How do I register for clozapine?
- Patient enrollment in the Clozapine REMS Program is confirmed prior to dispensing clozapine.
- You can enroll patients through your account on www.clozapinerems.com or by calling the Clozapine REMS Program Contact Center at 844-267-8678.
Is clozapine banned in America?
In general in the United States the use of clozapine is restricted to those people with schizophrenia who have failed first-line treatments. The reason for this restriction is its risk of severe side effects.
Why are there new clozapine REMS?
“The purpose of this new Clozapine REMS Program is to ensure that the benefits of a patient taking clozapine are greater than the potential life threatening risk of severe neutropenia, a well established rare adverse event,” said John J. Miller, MD, Editor in Chief of Psychiatric TimesTM.
Does clozapine have a black box warning?
Clozaril carries five serious warnings, called black box warnings, about possible severe side effects and drug interactions. 2 Because of these warnings, Clozaril can only be prescribed through a special program that restricts distribution called the Clozapine Risk Evaluation and Mitigation Strategies (REMS) Program.
How often should clozapine levels be checked?
Patients taking clozapine should receive routine weekly-to-monthly monitoring and maintain an ANC ≥1500/microL (≥1000/microL for benign ethnic neutropenia). Lower ANC levels require more frequent monitoring, and possible interruption of clozapine and/or reevaluation of its use.
How do I get REMS certification?
1. Complete and sign the Rosiglitazone REMS Prescriber Enrollment Form and submit it to the Rosiglitazone REMS Program. 2. Agree to complete and sign a Rosiglitazone REMS Patient Enrollment Form for each patient enrolled.
What doctor can prescribe clozapine?
Prescribers of CLOZAPINE in California
| Provider | Medicare Claims | State |
|---|---|---|
| SAMUEL KUGEL M.D. Psychiatry | 246 | California |
| LATHA NAIR M.D. Psychiatry | 241 | California |
| MARY SCHAEPPER M.D. Psychiatry | 235 | California |
| GREGORY JAECK Psychiatry | 235 | California |
Does clozapine shorten your life?
Importantly, mortality risk to these individuals may vary between the antipsychotics they are prescribed. A number of investigations, including several large scale cohort studies, have reported that clozapine has the lowest risk of all-cause mortality and suicide specifically compared to other antipsychotics.
Does clozapine cause memory problems?
Clozapine is an effective antipsychotic drug, but its effects on cognitive function are unclear. Previously, we found that clozapine caused a working memory deficit, which was reversed by nicotine. Hippocampal systems are important in determining clozapine effect on memory.
Why is clozapine a last resort?
Clozapine has unique and powerful side effects and risks, which often make it a drug of last resort.
Can clozapine be transferred between pharmacies?
Inpatient pharmacies do not need to obtain a PDA before dispensing clozapine. Patients currently treated with clozapine will be automatically transferred to the REMS program. Clozapine is an antipsychotic drug used to treat schizophrenia in patients whose symptoms are not controlled with standard treatment.
