What is the difference between Factor 5 and Factor 5 Leiden?
What is the difference between Factor 5 and Factor 5 Leiden?
What is Factor V Leiden Mutation? Factor V Leiden is a common change in a gene that controls a protein called Factor V. Factor V is a protein involved in blood clotting and the Factor V Leiden gene change (also called mutation) is linked to an increase risk of blood clots.
What is the best known hereditary clotting factor disorder?
Factor V(5) Leiden is the most common genetic condition that can lead to blood clots. Almost all people with factor V Leiden have one affected gene and one normal gene.
Can I give blood if I have Factor V Leiden?
People with factor V Leiden may donate blood, platelets or plasma safely, as long as they are not on an anticoagulant such as warfarin. Only a very few medicines prevent people from donating blood.
Can I take ibuprofen with Factor V Leiden?
It is important that people with Factor V deficiency should not use Non-Steroidal Anti-Inflammatory Drugs (NSAIDs such as ibuprofen) as this greatly increases the risk of bleeding. Other methods of pain relief should be used instead.
What is the prevalence of factor V Leiden?
Factor V Leiden is the most common inherited form of thrombophilia. Between 3 and 8 percent of the Caucasian (white) U.S. and European populations carry one copy of the factor V Leiden mutation, and about 1 in 5,000 people have two copies of the mutation. The mutation is less common in other populations.
What is the Leiden mutation?
The mutation is named factor V “Leiden” because it was originally discovered at the University of Leiden in the Netherlands, in 1994. Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission.
What are the chances of getting a blood clot with Leiden?
Still, it is estimated that 95% of people with factor V Leiden never develop a clot. When a clot does form, the clot most often occurs in your leg ( deep venous thrombosis or DVT) or lungs ( pulmonary embolism or PE).
What is the cause of factor FVL?
FVL is caused by a genetic mutation to the Factor V (or “factor 5”) gene. This gene helps our body make the coagulation factor V protein, which is one of the many proteins in our coagulation system that help our blood clot after an injury.
