What is the life expectancy of someone with Alpha 1?
What is the life expectancy of someone with Alpha 1?
People who continue to smoke and have Alpha-1 lung disease, have an average life expectance of about 60 years of age.
How does Prolastin C work?
Alpha-1 proteinase inhibitor works in the lower respiratory tract where it inhibits neutrophil elastase (NE), the enzyme that damages lung tissue. In clinical trials, alpha-1 proteinase inhibitor therapy increased the plasma levels of AAT.
What are alpha 1 medications?
Alpha-1 proteinase inhibitor injection, also called alpha 1-PI, is used to treat a certain type of emphysema (a lung condition). The emphysema is caused by the lack of a protein called alpha 1-antitrypsin (AAT) in the body. This medicine replaces the protein when the body does not produce enough.
How do you infuse Prolastin?
Infuse PROLASTIN-C LIQUID intravenously at 0.08 mL/kg/min as determined by patient response and comfort. The recommended dosage of 60 mg/kg takes approximately 15 minutes to infuse. PROLASTIN-C LIQUID is supplied in a 1,000 mg (approximate) single-use vial containing 20 mL of solution for injection.
Is Prolastin covered by Medicare?
Do Medicare prescription drug plans cover Prolastin C? Yes. 93% of Medicare prescription drug plans cover this drug.
What do alpha 1 blockers do?
The alpha-1 adrenergic receptor antagonists (also called alpha-blockers) are a family of agents that bind to and inhibit type 1 alpha-adrenergic receptors and thus inhibit smooth muscle contraction. Their major uses are for hypertension and for symptomatic benign prostatic hypertrophy.
What is the phenotype of alpha 1 antitrypsin deficiency?
Expression of Phenotype in Alpha-1 Antitrypsin Deficiency. Alpha-1 antitrypsin deficiency is congenital lack of a primary lung antiprotease, alpha-1 antitrypsin, which leads to increased protease-mediated tissue destruction and emphysema in adults.
What is augmentation therapy for alpha-1 antitrypsin?
A: Augmentation therapy is intended to augment (add to) the amount of alpha-1 antitrypsin protein (AAT) floating in the blood and bathing the tissues of the body in people with lung disease related to Alpha-1.
How is pulmonary disease treated with Alpha-1 antitrypsin?
Treatment of pulmonary disease is with purified human alpha-1 antitrypsin (60 mg/kg IV over 45 to 60 min given once/wk or 250 mg/kg over 4 to 6 h given once/mo [pooled only]), which can maintain the serum alpha-1 antitrypsin level above a target protective level of 80 mg/dL (35% of normal).
How does alpha-1 antitrypsin deficiency increase the risk of liver cancer?
Liver involvement increases the risk of liver cancer. In the lungs, alpha-1 antitrypsin deficiency increases neutrophil elastase activity, which facilitates tissue destruction leading to emphysema (especially in smokers, because cigarette smoke also increases protease activity).
