What is the main function of the juxtaglomerular apparatus?
What is the main function of the juxtaglomerular apparatus?
The juxtaglomerular apparatus functions to maintain blood pressure and to act as a quality control mechanism to ensure proper glomerular flow rate and efficient sodium reabsorption.
How does juxtaglomerular cells release renin?
Juxtaglomerular cells secrete renin in response to a drop in pressure detected by stretch receptors in the vascular walls, or when stimulated by macula densa cells. These cells also respond directly to a decrease in systemic blood pressure which is manifested as a lower renal perfusion pressure.
What is the Juxtamedullary apparatus?
The juxtaglomerular apparatus is the location of renin-secreting cells and the macula densa and lies at the junction between the loop of Henle and the distal nephron at which the tubule comes in close proximity to the afferent arteriole.16.
What hormone does juxtaglomerular apparatus release?
hormone renin
The juxtaglomerular cells synthesize the enzyme-hormone renin. Renin is released in response to a drop in either salt concentration (sensed by osmoreceptors in the macula densa) or blood pressure (sensed by mechano- or baroreceptors in the afferent arteriole).
How does renin affect GFR?
The macula densa responds by decreasing ATP release, and there is a subsequent decrease in calcium from the smooth muscle cells of the afferent arteriole. The ensuing result is vasodilation, and increased renin release in an attempt to increase GFR.
What is the Juxtaglomerular apparatus quizlet?
What is the main function of the Juxtaglomerular apparatus? To secrete Erythropoitein and Renin. What is Filtration? The movement of a fluid across a membrane whose pores restrict the passageway of solutes on the basis of size.
What triggers the Juxtaglomerular apparatus to release renin in the kidney?
Increased renin release from the juxtaglomerular cells is caused by several conditions: reduction in renal blood flow from heart failure, blood loss, hypotension or ischemia of the kidneys, sodium diuresis (excessive sodium loss in urine), and beta-adrenergic stimulation.
What are the 3 components of the Juxtaglomerular?
The three cellular components of the apparatus are the macula densa, extraglomerular mesangial cells, and juxtaglomerular cells (also known as granular cells)[WP].
Is renin secreted by juxtaglomerular cells?
Renin is secreted by juxtaglomerular cells located in the afferent arteriole. At the cellular level, renin secretion is mediated by the fusion of renin-containing granules with the luminal membrane of the cell.
Where are Juxtaglomerular cells?
The juxtaglomerular granular cells are located primarily in the walls of the afferent and, less commonly, the efferent arterioles. They exhibit features of both smooth muscle cells and secretory epithelial cells and therefore have been called epithelioid or myoepithelial cells.
Why is it called the juxtaglomerular apparatus?
The juxtaglomerular apparatus is named because it is next to (juxta-) the glomerulus. The juxtaglomerular apparatus consists of three types of cells: the macula densa, a part of the distal convoluted tubule of the same nephron juxtaglomerular cells, (also known as granular cells) which secrete renin
How does the juxtaglomerular apparatus increase renin secretion?
Through the signaling of kidney baroreceptors located in the afferent arterioles, juxtaglomerular apparatus cells increase or reduce the renin secretion in response to decreased or increased circulating blood volume or renal blood flow, respectively.
What are macula densa and macula juxtaglomerular?
They are: the macula densa, a part of the distal convoluted tubule of the same nephron juxtaglomerular cells, which secrete renin, specialized smooth muscle cells of the afferent arteriole, which supplies blood to the glomerulus extraglomerular mesangial cells
What are the types of juxtaglomerular cells?
The juxtaglomerular apparatus consists of three cell types. These are: the macula densa, a part of the thick ascending limb of loop of Henle of the same nephron. juxtaglomerular cells, which secrete renin, specialized smooth muscle cells of the afferent arteriole, which supplies blood to the glomerulus.
