What is the molecular weight of histone H3?
What is the molecular weight of histone H3?
15 kDa
Histone H3 is primarily acetylated at lysines 9, 14, 18, and 23 and have a theoretical molecular weight of 15 kDa.
What is phospho histone H3?
Phospho-histone H3 (pHH3) is a protein phosphorylated during chromatin condensation in mitosis, and thus anti-pHH3 immunocytochemistry is able to assess mitotic activity.
What is pHH3?
Phosphohistone H3 (pHH3) is a recently described marker specific for cells undergoing mitosis. Serine 10 of Histone H3 is phosphorylated in association with mitotic chromatin condensation in late G2 and M phase of the cell cycle and thus, pHH3 can distinguish mitosis from apoptotic nuclei (1).
What is the molecular weight of histone?
The core histones [molecular masses ~11,300Da (H4) to 15,300 (H3)] show a high degree of evolutionary sequence conservation, consistent with their role as organizing structural components in a common mode of DNA packaging in eukaryotes.
What is the molecular weight of H4?
CID 15178913
| PubChem CID | 15178913 |
|---|---|
| Structure | Find Similar Structures |
| Molecular Formula | H4 |
| Molecular Weight | 4.032 |
| Dates | Modify 2021-12-18 Create 2007-02-09 |
What compound is h4?
Heliocide H4 belongs to the class of organic compounds known as hydroxyanthraquinones. Hydroxyanthraquinones are compounds containing a hydroxyanthraquinone moiety, which consists of an anthracene bearing a quinone, and hydroxyl group.
What is phospho-histone H3 (Ser10) antibody?
Phospho-Histone H3 (Ser10) Antibody detects endogenous levels of histone H3 only when phosphorylated at Ser10; however, this antibody does not detect phosphorylated Ser10 when Lys9 is acetylated or methylated. This antibody does not cross-react with histone H3 phosphorylated at Ser28.
Where is histone H3 acetylated?
Histone H3 is primarily acetylated at Lys9, 14, 18, 23, 27, and 56. Acetylation of H3 at Lys9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms (2,3). Phosphorylation at Ser10, Ser28, and Thr11 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis (8-10).
Is this antibody cross-reactive with other phosphorylated histones?
This antibody is not cross-reactive with other phosphorylated histones or with acetylated histones. Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome.
