What is the most common side effect of G-CSF?

What is the most common side effect of G-CSF?

What side effects may I notice from receiving this medicine?

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue.
• back pain.
• dizziness or feeling faint.
• fever.
• pain, redness, or irritation at site where injected.
• pinpoint red spots on the skin.
• shortness of breath or breathing problems.

Is CSF in bone marrow?

The CSF was reported as non-diagnostic as it contains predominantly bone marrow elements, which are indicative of sampling error and as such, an unsuitable specimen for accurate assessment. Correlation with microbiology and hematology studies was recommended.

What is G-CSF primed bone marrow?

Granulocyte–colony-stimulating factor (G-CSF)–primed allogeneic bone marrow: significantly less graft-versus-host disease and comparable engraftment to G-CSF–mobilized peripheral blood stem cells. From the Bone Marrow Transplant Unit, Royal Brisbane Hospital, Herston, Australia.

What are the side effects of G-CSF injections?

One or more of the following signs and symptoms were observed shortly after the subcutaneous injection of G-CSF: dyspnea, chest pain, nausea, hypoxemia, diaphoresis, anaphylaxis, syncope and flushing.

Can G-CSF cause leukemia?

G-CSF use has been associated with later development of myelodysplastic syndromes/acute myelogenous leukemia (MDS/AML) in several clinical circumstances.

Why does G-CSF cause bone pain?

Background: The bone pain frequently emerges as one of the side effects of G-CSF administration. Rising pressure within bone marrow by increased granulocytes, edema within bone marrow by histamine release, and increased level of bradykinin are thought to be the mechanisms underlying it.

What are G-CSF injections?

G-CSF injections are a synthetic version of this naturally occurring growth factor. G-CSF injections are given before you donate your stem cells to boost your white cells and to release stem cells into the bloodstream ready to collect. G-CSF is also given to some patients receiving treatment for cancer.

What produces G-CSF?

Human G-CSF is produced mainly by monocytes and macrophages (2), but is also produced by fibroblasts (3), endothelial cells (4), and bone marrow stromal cells (5).

Does G-CSF affect platelet count?

Primarily, G-CSF stimulates the bone marrow to produce granulocytes and stem cells. A decreased platelet count was occasionally observed after G-CSF injection. A previous study indicated that G-CSF also increases platelet turnover and loss.

Can filgrastim cause leukemia?

This medicine may cause blood or bone marrow problems (eg, myelodysplastic syndrome, acute myeloid leukemia) in patients with breast or lung cancer.

How quickly does G-CSF work?

This usually takes 5 to 7 days, although it can be longer. Long-acting G-CSF is given as a single injection the day after chemotherapy has completed. If you are having G-CSF before a stem cell transplant, you usually have your first injection 4 to 6 days before your stem cells are going to be collected.

What is G-CSF and how does it affect stem cells?

G-CSF also makes some stem cells move from the bone marrow into the blood. Stem cells are the cells in the bone marrow that make red blood cells, white cells and platelets. Before a stem cell transplant, you have G-CSF to stimulate the bone marrow to produce stem cells and release them into the blood.

What is G-CSF and is it used on the NHS?

This type of G-CSF is not commonly used in the NHS. Growth factors are proteins made in the body. Some of them make the bone marrow produce blood cells. G-CSF is a type of growth factor that makes the bone marrow produce more white blood cells so it can reduce the risk of infection after some types of cancer treatment.

What is granulocyte colony stimulating factor G-CSF?

Granulocyte colony stimulating factor (G-CSF) G-CSF is a type of growth factor. You might have G-CSF after chemotherapy to help your white blood cells recover after treatment. Or you might have it before and after a stem cell transplant.

What is pegylated G-CSF and how is it used?

G-CSF is a type of growth factor. You might have G-CSF after chemotherapy to help your white blood cells recover after treatment. Or you might have it before and after a stem cell transplant. Pegylated G-CSF stays in the body for longer so you have treatment less often than with the other types of G-CSF.