What is the pathophysiology of cardiomyopathy?
What is the pathophysiology of cardiomyopathy?
The hallmark pathophysiologic feature of DCM is systolic dysfunction of the left or both ventricles. Reduced sarcomere contractility increases ventricular volumes to maintain cardiac output through the Frank-Starling mechanism, producing the thin-walled dilated LV appearance that is observed in overt DCM.
What is heart failure caused by metabolic process?
Heart failure (HF) is associated with metabolic changes that cause a progressive impairment of cardiac and skeletal muscle high-energy phosphate production. As a consequence of the impaired cardiac metabolism, other processes are activated in the failing heart that further exacerbate the progression of HF.
How does metabolic syndrome affect the heart?
Heart and blood vessel disease. These plaques can narrow and harden your arteries, which can lead to a heart attack or stroke.
What metabolic process occurs in the heart?
Metabolism in the Normal Heart Under normoxic conditions, >95% of ATP generated in the heart is derived from oxidative phosphorylation in the mitochondria. The remaining 5% comes mainly from glycolysis and to a lesser extent from the citric acid cycle (Krebs cycle).
What is the most common type of cardiomyopathy?
Dilated cardiomyopathy (DCM) is the most common type, occurring mostly in adults 20 to 60. It affects the heart’s ventricles and atria, the lower and upper chambers of the heart, respectively.
What are the 5 risk factors associated with metabolic syndrome?
The five risk factors are:
- increased blood pressure (greater than 130/85 mmHg)
- high blood sugar levels (insulin resistance)
- excess fat around the waist.
- high triglyceride levels.
- low levels of good cholesterol, or HDL.
Which components may result in metabolic syndrome?
Metabolic syndrome is a condition that includes a cluster of risk factors specific for cardiovascular disease. The cluster of metabolic factors include abdominal obesity, high blood pressure, impaired fasting glucose, high triglyceride levels, and low HDL cholesterol levels.
What is involved in pathophysiology?
Studies of pathophysiology are concerned with the investigation of biological processes that are directly related to disease processes of physical, mental, or psychophysiological conditions and disorders (e.g., alterations in the endocrine system, in certain neurotransmitters, or inflammatory parameters related to the …
What is the life expectancy of cardiomyopathy?
Life Expectancy and Survival Rates. 5-year survival rate for Dilated cardiomyopathy: about 50 percent of patients with dilated cardiomyopathy live 5 years once heart failure is diagnosed; about 25 percent live 10 years after such a diagnosis.
