What is the pKa of imidazole?
What is the pKa of imidazole?
6.8
Imidazole is an important intracellular buffer because it is a building block for proteins and enzymes and because it has a pKa (at 37°C) of 6.8 (close to intracellular pH).
What are the uses of imidazole?
Imidazole has become an important part of many pharmaceuticals. Synthetic imidazoles are present in many fungicides and antifungal, antiprotozoal, and antihypertensive medications. Imidazole is part of the theophylline molecule, found in tea leaves and coffee beans, that stimulates the central nervous system.
How do you synthesis imidazole?
A ketone oxidation, employing catalytic HBr and DMSO, followed by imidazole condensation with aldehydes provides 2,4(5)-disubstituted imidazoles in good yields. A three-step synthesis of 20 kinase inhibitors was achieved by employing this oxidation-condensation protocol, followed by bromination and Suzuki coupling.
Which is an official drug of imidazole?
Sertaconazole is an imidazole approved for treatment of tinea pedis. Luliconazole is an imidazole approved for tinea pedis, tinea cruris, and tinea corporis.
What is the pH of imidazole?
6.2-7.8
Application: Imidazole buffer Solution is a buffer used in the pH range of 6.2-7.8, and a chelator used for the binding of various divalent cations.
Which drug contain imidazole nucleus?
There are different examples of commercially available drugs in the market which contains 1, 3-diazole ring such as clemizole (antihistaminic agent), etonitazene (analgesic), enviroxime (antiviral), astemizole (antihistaminic agent), omeprazole, pantoprazole (antiulcer), thiabendazole (antihelmintic), nocodazole ( …
Why is imidazole Basic?
Imidazole is more basic than pyridine. This is due to the greater resonance stabilization of the positive charge of its conjugate acid. Greater the pka value, the more basic the species become. Originally Answered: How can you explain imidazole being more basic than pyridine?
How do you make thiazole?
Thiazoles were obtained in good yields by the reaction of 1H-1-(1′-alkynyl)-5-methyl-1,2,3-benziodoxathiole 3,3-dioxides with thioamides.
What are azoles used for?
Azole antifungal agents can be used to treat fungal infections of the body and skin, including athlete’s foot, onychomycosis (fungal nail infections), ringworm, and vaginal candidiasis.
What is pyrazole used for?
Pyrazoles are reported to possess a wide range of biological activities in literature such as anti-microbial, anti-fungal, anti-tubercular, anti-inflammatory, anti-convulsant, anticancer, anti-viral, angiotensin converting enzyme (ACE) inhibitory, neuroprotective, cholecystokinin-1 receptor antagonist, and estrogen …
What can TosMIC be used for?
For example, TosMIC can be used as a C-N=C synthon for the synthesis of various heterocycles, such as oxazoles ( Van Leusen Oxazole Synthesis ), imidazoles ( Van Leusen Imidazole Synthesis ), pyrroles, 1,2,4-triazoles and many more.
pKa of imidazoles. Compound p K a Imidazolium 7.38 2-Aminoimidazolium 8.46 1-Methyl-2-aminoimidazolium 8.65 4,5-Dimethyl-2-aminoimidazolium 9.21.
How do you make imidazole from aldimines?
Amphoterism. The Van Leusen Imidazole Synthesis allows the preparation of imidazoles from aldimines by reaction with tosylmethyl isocyanide (TosMIC). The reaction has later been expanded to a two-step synthesis in which the aldimine is generated in situ: the Van Leusen Three-Component Reaction (vL-3CR).
What is imidazole 1?
Imidazole 1 is a five-membered aromatic molecule containing two annular nitrogen atoms. One nitrogen behaves like a pyrrole-type nitrogen and the other one shows a close resemblance to a pyridine-type nitrogen.
