What is the purpose of TTM?

What is the purpose of TTM?

Targeted temperature management (TTM) previously known as therapeutic hypothermia or protective hypothermia is an active treatment that tries to achieve and maintain a specific body temperature in a person for a specific duration of time in an effort to improve health outcomes during recovery after a period of stopped …

What are 3 key elements of the TTM protocol?

Treatment protocols Three phases of TTM include induction, maintenance, and rewarming.

What is an absolute contra indication to targeted temperature management?

Further, they recommend selecting and maintaining a constant temperature between 32 degrees C and 36 degrees C during TTM. Absolute contraindications to TTM are an awake and responsive patient, DNR, active non-compressible bleeding and the need for immediate surgery.

What is the cause of hypothermia?

Hypothermia is caused by prolonged exposures to very cold temperatures. When exposed to cold temperatures, your body begins to lose heat faster than it’s produced. Lengthy exposures will eventually use up your body’s stored energy, which leads to lower body temperature.

What temperature should TTM be?

7 The American Heart Association’s (AHA) 2015 Cardiopulmonary Resuscitation (CPR) Guidelines state that any comatose patient who achieves return of spontaneous circulation (ROSC) after a cardiac arrest should be treated with TTM and maintained at a constant temperature between 32[degrees]C and 36[degrees]C for at least …

When is targeted temperature management used?

The task force recommends targeted temperature management for adults with out-of-hospital cardiac arrest with an initial shockable rhythm at a constant temperature between 32°C and 36°C for at least 24 hours.

What methods are used for targeted temperature management?

Most studies have found it necessary to use both cooling blankets and ice packs to achieve the temperature goal. Other methods such as ice lavage, cold saline infusion, and endovascular methods may be used to help achieve target temperature.

When should TTM be initiated?

TTM should be induced and maintained at the selected target temperature for 24 hours, and rewarmed gradually at a rate not faster than 0.5°C per hour. Every hour of delay in TTM after ROSC increases mortality by 20%. Thus, TTM should be initiated as soon as possible after ROSC.

What happens if body temperature is low?

When your body temperature drops, your heart, nervous system and other organs can’t work normally. Left untreated, hypothermia can lead to complete failure of your heart and respiratory system and eventually to death. Hypothermia is often caused by exposure to cold weather or immersion in cold water.

What is the difference of hyperthermia and hypothermia?

Hyperthermia vs. You may be familiar with the term hypothermia. This happens when your body’s temperature drops to dangerously low levels. The opposite can also occur. When your temperature climbs too high and threatens your health, it’s known as hyperthermia.

What does TTM mean in cardiology?

argeted temperature management (TTM), previously known as mild therapeutic hypothermia, in selected patients surviving out-of-hospital sudden cardiac arrest (OHCA) can significantly improve rates of long-term neurologically intact survival, and it may prove to be one of the most important clinical advancements in the …

Who needs targeted temperature management?

How are large PAHs produced in the HACA mechanism?

In the HACA mechanism, the preferred production of large PAHs, either benzenoid-PAHs or CP-PAHs, strongly depends on growth pathways initiating from naphthalene.

What are the pathophysiological mechanisms of fever?

There are a number of pathophysiological mechanisms for the deleterious effects of a fever, classified as follows (Fig. 2): 1 Direct cellular damage 2 Local effects, e.g. stimulation of cytokines and inflammatory response 3 Systemic effects, e.g. gut bacterial translocation More

What is the hydrogen abstraction acetylene addition (HACA) mechanism?

It is widely accepted that the hydrogen abstraction acetylene addition (HACA) mechanism accelerates the formation of benzenoid polycyclic aromatic hydrocarbons (PAHs), like pyrene, from naphthylene via phenanthrene and stops at the formation of cyclopentaring-fused products like acenaphthylene/pyracyclene.

Is hypothermia an unnecessarily aggressive approach to avoid fever?

It is increasingly clear that hypothermia is merely an unnecessarily aggressive approach to avoiding fever. With two robust studies showing no benefit from hypothermia (TTM1 & TTM2), it’s no longer possible to justify the cost and iatrogenic harms of hypothermia (outside of a clinical trial).