What is the SLC6A3 gene?
What is the SLC6A3 gene?
The SLC6A3 gene provides instructions for making a protein called the dopamine transporter or DAT. This protein is embedded in the membrane of certain nerve cells (neurons) in the brain, where it transports a molecule called dopamine into the cell.
What does the dopamine transporter gene do?
The dopamine transporter (also dopamine active transporter, DAT, SLC6A3) is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol. In the cytosol, other transporters sequester the dopamine into vesicles for storage and later release.
What does the DAT1 gene do?
The dopamine transporter gene (DAT1/SLC6A3) is a membrane-spanning protein that mediates the reuptake of dopamine from the synapse. It has been associated with bipolar disorder and ADHD.
What type of transporter is dopamine reuptake transporter?
The dopamine transporter (DAT) is a presynaptic monoamine transporter that mediates dopamine reuptake from the synapse. Cocaine intoxication and addiction are mediated primarily through dopaminergic pathways, with acute effects due to inhibition of dopamine uptake by binding to the DAT.
What is the DRD2 gene?
DRD2 (Dopamine Receptor D2) is a Protein Coding gene. Diseases associated with DRD2 include Cocaine Dependence and Substance Dependence. Among its related pathways are Development Dopamine D2 receptor transactivation of EGFR and Signaling by GPCR.
How is dopamine transported in the brain?
Dopamine is transported across the membrane from the relatively low-concentration synaptic cleft into the relatively high-concentration presynaptic neuron. This is an energetically expensive process, because the dopamine molecules must be transported against their concentration gradient.
How does dopamine reuptake work?
What Are NDRIs? NDRIs block the transport of norepinephrine and dopamine back into the brain cells that released them. In turn, a greater number of active neurotransmitters remains available in the brain, which may over time lead to changes that help relieve the symptoms of depression.
How is dopamine transported?
Is dopamine transporter active or passive?
Dopamine transporter function and regulation The availability of DA in the brain is modulated by the dopamine transporter (DAT), a plasma membrane protein that actively translocates released transmitter from the extracellular space into the presynaptic neuron.
Which of the following affects dopamine transport?
Video Solution: Which of the following affects dopamine transport? Coca alkaloids interferes with the transport of the neuro-transmitter dopamine.
What is dopamine transporter deficiency syndrome (DAT)?
Mutations in DAT have been shown to cause dopamine transporter deficiency syndrome, an autosomal recessive movement disorder characterized by progressively worsening dystonia and parkinsonism. The dopamine transporter is the target of substrates, dopamine releasers, transport inhibitors and allosteric modulators.
What is the function of the dopamine active transporter?
View/Edit Mouse. The dopamine transporter (also dopamine active transporter, DAT, SLC6A3) is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol. In the cytosol, other transporters sequester the dopamine into vesicles for storage and later release.
What is the driving force for dopamine reuptake in DAT?
The driving force for DAT-mediated dopamine reuptake is the ion concentration gradient generated by the plasma membrane Na + /K + ATPase. In the most widely accepted model for monoamine transporter function, sodium ions must bind to the extracellular domain of the transporter before dopamine can bind.
What is the function of dopamine and Dat in the brain?
Dopamine underlies several aspects of cognition, including reward, and DAT facilitates regulation of that signal. DAT is a symporter that moves dopamine across the cell membrane by coupling the movement to the energetically-favorable movement of sodium ions moving from high to low concentration into the cell.
