What is the starting material for synthesis of methyldopa?
What is the starting material for synthesis of methyldopa?
i. 4-hydroxy-3-methoxy phenylacetone is taken as starting material.
What is chemical name of methyldopa?
Methyldopa sesquihydrate
| PubChem CID | 38852 |
|---|---|
| Chemical Safety | Laboratory Chemical Safety Summary (LCSS) Datasheet |
| Molecular Formula | C20H32N2O11 |
| Synonyms | METHYLDOPA SESQUIHYDRATE alpha-Methyldopa sesquihydrate 41372-08-1 UNII-56LH93261Y L-3-(3,4-Dihydroxyphenyl)-2-methylalanine sesquihydrate More… |
| Molecular Weight | 476.5 |
What is methyldopa mechanism?
Mechanism of Action Alpha-methyldopa is converted to methyl norepinephrine centrally to decrease the adrenergic outflow by alpha-2 agonistic action from the central nervous system, leading to reduced total peripheral resistance and decreased systemic blood pressure.
How do you make methyldopa?
Under an acidic condition, the preparation of methyldopa by nitrile group hydrolysis and demethylation hydrolysis of alpha-methyl-(3,4-dimethoxyphenyl)-alpha-aminopropionitrile (or hydrochloride) requires a long period, a large material using amount, and heating hydrolysis of high-concentration acids (and the long-time …
What is the chemical name for clonidine?
Catapres® (clonidine hydrochloride, USP) is a centrally acting alpha-agonist hypotensive agent available as tablets for oral administration in three dosage strengths: 0.1 mg, 0.2 mg and 0.3 mg.
How is methyldopa metabolized?
Methyldopa is extensively metabolized in the liver to form the main circulating metabolite in the plasma, alpha (α)-methyldopa mono-O-sulfate. Its other metabolites also include 3-O-methyl-α-methyldopa; 3,4-dihydroxyphenylacetone; α-methyldopamine; and 3-O-methyl-α-methyldopamine.
Who manufactures methyldopa?
The largest manufacturers and suppliers of methyldopa medications include Merck, LGM Pharma, Icn Pharmaceuticals, and Laboratoires Confab, Mylan, and Sanofi-Aventis. Producers and suppliers market both generic and trade name formulations of the drug.
How is methyldopa activated?
Methyldopa is well-absorbed orally, and has a half-life of about 2 hours. The mechanism of action in the CNS is not known. It is activated by decarboxylation to α-methyl-noradrenaline, a false transmitter with a much weaker action than noradrenaline.
What is the pharmacokinetics of methyldopa?
Physicochemical determination of methyldopa shows that bi-phasic elimination occurs after both intravenous and oral administration, the half-life of the alpha-phase being 0.21 hours (range 0.16 to 0.26 hours) and of the beta-phase 1.28 hours (range 1.02 to 1.69 hours) in normal subjects.
What category of drug is methyldopa?
Methyldopa is in a class of medications called antihypertensives. It works by relaxing the blood vessels so that blood can flow more easily through the body. High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body.
How is clonidine synthesized?
Clonidine, 2-(2,6-dichlorophenylamino)imidazoline, is synthesized from 2,6-dichloroaniline, the reaction of which with ammonium thiocyanate gives N-(2,6- dichlorophenyl)thiourea. Methylation of this product, followed by the subsequent reaction with ethylene diamine gives clonidine.
What is the mechanism of action of methyldopa?
Methyldopa is an α 2 -Adrenergic agonist. [1] Present in colorless crystals form, it is present in sesquihydrate form. i. Methyldopa converts into its metabolite, α-methylnorephrine which stimulates the central inhibitory α-adrenergic receptors.
What class of organic compound is methyldopa?
Methyldopa, also known as alpha-methyldopa or aldomet, belongs to the class of organic compounds known as phenylpropanoic acids. Phenylpropanoic acids are compounds with a structure containing a benzene ring conjugated to a propanoic acid. Methyldopa is a drug which is used for use in the treatment of hypertension.
What is the color of methyl dopa?
Methyl dopa appears as colorless or almost colorless crystals or white to yellowish-white fine powder. Almost tasteless. In the sesquihydrate form. pH (saturated aqueous solution) about 5.0.
What is the Grignard reaction for triphenylmethanol?
Grignard Reaction: Synthesis of Triphenylmethanol *NOTE: Grignard reactions are very moisture sensitive, so all the glassware in the reaction (excluding the work-up) should be dried in an oven with a temperature of > 100oC overnight.
