What is the use of para-aminosalicylic acid?
What is the use of para-aminosalicylic acid?
4-Aminosalicylic acid, also known as para-aminosalicylic acid (PAS) and sold under the brand name Paser among others, is an antibiotic primarily used to treat tuberculosis. Specifically it is used to treat active drug resistant tuberculosis together with other antituberculosis medications.
What is the mechanism of Para-aminosalicylic acid?
It inhibits the onset of bacterial resistance to streptomycin and isoniazid. The mechanism of action has been postulated to be inhibition of folic acid synthesis (but without potentiation with antifolic compounds) and/or inhibition of synthesis of the cell wall component, mycobactin, thus reducing iron uptake by M.
What is the mechanism of action of PAS?
We provide evidences that PAS is incorporated into the folate pathway by dihydropteroate synthase (DHPS) and dihydrofolate synthase (DHFS) to generate a hydroxyl dihydrofolate antimetabolite, which in turn inhibits DHFR enzymatic activity.
What is the elements present in the para amino salicylic acid *?
4-aminosalicylic acid is an aminobenzoic acid that is salicylic acid substituted by an amino group at position 4. It has a role as an antitubercular agent. It is an aminobenzoic acid and a member of phenols. It derives from a salicylic acid.
What is the brand name of chlorambucil?
Chlorambucil(Leukeran) generic is a cytotoxic chemotherapy drug, prescribed for chronic lymphocytic leukemia, non-Hodgkin’s lymphoma, Hodgkin’s disease and lymphosarcoma.
Which condition is a common adverse effect of Para aminosalicylic acid?
The most common side effect is gastrointestinal intolerance manifested by nausea, vomiting, diarrhea, and abdominal pain.
Which is the precursor for the synthesis of PAs?
S- adenosylmethionine (SAM) in the PA biosynthetic pathway is also a precursor for ethylene synthesis (Figure 1), and studies have demonstrated that PAs synthesis competes with ethylene synthesis ( Lasanajak et al., 2014).
How do you use diethylcarbamazine?
Diethylcarbamazine should be taken immediately after meals. To help clear up your infection completely, keep taking this medicine for the full time of treatment, even if your symptoms begin to clear up after a few days.
What dapsone is used for?
Dapsone is used to treat leprosy (Hansen’s disease) and to help control dermatitis herpetiformis, a skin problem. When it is used to treat leprosy, dapsone may be given with one or more other medicines.
What is the generic name for chlorambucil?
Chemocare.com uses generic drug names in all descriptions of drugs. Leukeran is the trade name for chlorambucil. In some cases, health care professionals may use the trade name leukeran when referring to the generic drug name chlorambucil.
What is para-aminosalicylic acid (PAS)?
Wilson J, et al. (2003) Para-aminosalicylic acid (PAS) desensitization review in a case of multidrug-resistant pulmonary tuberculosis. Int J Tuberc Lung Dis 7, 493 7. ethambutol (ETH) in the early 1960s. 6 It is bacteristatic but may help to slow development of resistance to other drugs, especially INH and streptomycin (STR) [DrugBank].
What is aminosalicylic acid used for?
Aminosalicylic Acid is an analog of para-aminobenzoic acid with antitubercular activity. Aminosalicylic acid exerts its bacteriostatic activity against Mycobacterium tuberculosis by competing with PABA for enzymes involved in folate synthesis, thereby suppressing growth and reproduction of M. tuberculosis, eventually leading to cell death.
How does aminosalicylic acid work to treat tuberculosis?
Aminosalicylic acid exerts its bacteriostatic activity against Mycobacterium tuberculosis by competing with PABA for enzymes involved in folate synthesis, thereby suppressing growth and reproduction of M. tuberculosis, eventually leading to cell death. 4-amino-2-hydroxybenzoic acid
What is the structure of 4-Aminosalicylic acid?
4-aminosalicylic acid is an aminobenzoic acid that is salicylic acid substituted by an amino group at position 4. It has a role as an antitubercular agent. It is an aminobenzoic acid and a member of phenols. It derives from a salicylic acid. It is a conjugate acid of a 4-aminosalicylate (1-).
