What is TuJ1 antibody?
What is TuJ1 antibody?
The TUJ1 antibody reacts with beta-tubulin III, an ~50 – 55 kDa structural protein that is a component of tubulin. The beta III isoform of tubulin, also known as neuron-specific class III beta-tubulin, is expressed primarily in neurons and is widely used as a marker to distinguish neurons from other cell types.
What does beta tubulin mark for?
Since it was discovered that the human brain generates new neurons from stem cell pools, beta tubulin III has been used as a marker of positive neuronal identity in many research studies.
What is b3 tubulin?
Class III β-tubulin, otherwise known as βIII-tubulin (β3-tubulin) or β-tubulin III, is a microtubule element of the tubulin family found almost exclusively in neurons, and in testis cells. In humans, it is encoded by the TUBB3 gene. TUBB3 inactivation impairs neural progenitor proliferation.
What are neural markers?
A neuronal lineage marker is an endogenous tag that is expressed in different cells along neurogenesis and differentiated cells such as neurons. It allows detection and identification of cells by using different techniques. A neuronal lineage marker can be either DNA, mRNA or RNA expressed in a cell of interest.
What is the function of the neurofilament?
The principal function of the neurofilaments is in maintenance and support of the cytoskeleton. Neurofilaments that are phosphorylated are transported down into the axon, where they maintain the size and caliber of the axon.
What is the Beta III isoform of tubulin?
The beta III isoform of tubulin, also known as neuron-specific class III beta-tubulin, is expressed primarily in neurons and is widely used as a marker to distinguish neurons from other cell types. Beta-tubulin III contributes to microtubule formation in neuronal cell bodies and axons, a function involving GTP binding,…
What is Tuj1 antibody?
The TUJ1 antibody reacts with beta-tubulin III, an ~50 – 55 kDa structural protein that is a component of tubulin. Tubulin is the major component of microtubules within the cytoskeleton and is assembled from heterodimers of alpha and beta tubulin subunits. The beta III isoform of tubulin, also known as neuron-specific class III…
What is anti beta tubulin III antibody?
Anti-Beta-Tubulin III Antibody, Clone TUJ1. Overview. The TUJ1 antibody reacts with beta-tubulin III, an ~50 – 55 kDa structural protein that is a component of tubulin. Tubulin is the major component of microtubules within the cytoskeleton and is assembled from heterodimers of alpha and beta tubulin subunits.
What is the beta tubulin protein family?
This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules.
