What race/ethnicity carries the cystic fibrosis trait?

What race/ethnicity carries the cystic fibrosis trait?

Cystic fibrosis is a common genetic disease within the white population in the United States. The disease occurs in 1 in 2,500 to 3,500 white newborns. Cystic fibrosis is less common in other ethnic groups, affecting about 1 in 17,000 African Americans and 1 in 31,000 Asian Americans.

Are certain ethnicities more prone to cystic fibrosis?

Cystic fibrosis can affect people of any ethnicity and in any region in the world. The only known risk factors are race and genetics. Among Caucasians, it’s the most common autosomal recessive disorder.

How many Caucasians are carriers of cystic fibrosis?

Cystic fibrosis (CF) is typically described as one of the most common lethal autosomal recessive disorders in North America. About 1 in 25–30 Caucasians are carriers of CF mutations, whereas the carrier frequencies in other ethnic and racial groups are lower.

Is Cystic Fibrosis more common in Caucasian?

Cystic fibrosis is found in all ethnic groups, but is most common in Caucasians. * About 1 in 2500 Caucasians is born with the disease. The carrier frequency of the several ethnic groups is shown below. The chance of being a carrier is greater for those who have a family history of CF.

What race gets cystic fibrosis the most?

Cystic fibrosis is most common among Caucasians. In the U.S., the chances of being a carrier of a CFTR mutation are: 1 in 29 Caucasian-Americans. 1 in 46 Hispanic-Americans.

Which gene is linked to CF?

Every person has two copies of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. A person must inherit two copies of the CFTR gene that contain mutations — one copy from each parent — to have cystic fibrosis.

How many Europeans have cystic fibrosis?

The results of literature reviews, surveys, and registry analyses revealed a mean prevalence of 0.737/10,000 in the 27 EU countries, which is similar to the value of 0.797 in the United States, and only one outlier, namely the Republic of Ireland at 2.98.

Why is CF so prevalent in Ireland?

In Ireland, of those living with CF, 55.6% have two copies of F508del while 36.0% have one copy of it1. This mutation is a more common cause of CF in Ireland than in many other countries. The G551D is the second most common mutation. Within Europe, Ireland has the highest frequency of G551D mutations1,2.

What are The racial predilections of cystic fibrosis?

Cystic fibrosis is most common among Caucasians. In the U.S., the chances of being a carrier of a CFTR mutation are: 1 in 29 Caucasian-Americans 1 in 46 Hispanic-Americans

What percentage of carriers of cystic fibrosis are parents?

Cystic fibrosis (25%) CF carriers (50%) Unaffected (25%) Parents (CF carriers) Potential children. Who should consider carrier testing? An estimated 10 million people in the United States are carriers of cystic fibrosis. Individuals with a relative who is affected with or a carrier of CF should consider testing.

How common is cystic fibrosis (CF) in the US?

Following are estimates of the CF gene mutation carriers in the United States by ethnicity: 1 Caucasians: one in 29 2 Hispanics: one in 46 3 African-Americans: one in 65 4 Asian-Americans: one in 90

What is the prevalence of cystic fibrosis (CF) mutations in South Africa?

A further three CFTR mutations, A559T, S1255X, and 444delA, which had been found in African-American CF patients, were not identified in the patients or in over 373 healthy subjects tested. The 3120+1G→A mutation has a carrier frequency of 1 in 91 (8/728) in South African blacks with a 95% confidence interval of 1 in 46 to 1 in 197.