Which cells express Csf1r?
Which cells express Csf1r?
The expression of Csf1r mRNA is restricted to myeloid cells. During embryonic development, Csf1r mRNA is expressed in the earliest macrophages identifiable in the yolk sac and transcription of this gene in pluripotent bone marrow (BM) progenitors is the hallmark of commitment to the monocyte–macrophage lineage.
What is Csf1r gene?
The CSF1R gene provides instructions for making a protein called the colony stimulating factor 1 receptor (CSF-1 receptor). This protein is found in the outer membrane of certain cell types.
When stimulated by M-CSF what type of cell can become an osteoclast?
With stimulation by M-CSF, GMP further differentiates into cells of the monocyte/macrophage lineage (35,36), which are considered osteoclast precursors. In particular, committed osteoclast precursors express Mac-1, c-Fms and RANK, but not c-Kit (37).
Do monocytes express CSF1R?
By whole blood fluorescent activated cell sorting (FACS), CSF1R displays highest expression in monocytes [median fluorescent intensity (MFI): 1983], distinct from lymphocytes and neutrophils (MFI: 366), Fig.
What does C FMS stand for?
CFMS
| Acronym | Definition |
|---|---|
| CFMS | County Financial Management System (Colorado) |
| CFMS | Columbus Folk Music Society (Columbus, OH) |
| CFMS | Central Financial Management System |
| CFMS | Comité Français de Mécanique des Sols et de Géotechnique |
What produces M-CSF?
M-CSF is produced by osteoblasts and osteoblast precursors, but large amounts of M-CSF are also produced by osteocytes. M-CSF is present in two distinct biologically active forms, a membrane-bound and a secreted form, that result from alternative splicing of the CSF1 gene.
Where is M-CSF produced?
M-CSF is produced in the bone marrow and by endothelial cells, fibroblasts, and mononuclear phagocytes. Its effects are felt locally; that is, M-CSF is not found in the blood circulation.
What is the function of CSF1R receptor?
Function. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSF1R through a process of oligomerization and trans-phosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/ PDGF receptor family of tyrosine-protein kinases.
How does ligand bind to CSF1R?
Ligand binding activates CSF1R through a process of oligomerization and trans- phosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/ PDGF receptor family of tyrosine-protein kinases. This section needs to be updated.
What does cdcd115 mean?
CD115 is expressed by monocyte, macrophage, osteoclast, and some epithelial cells. It is a 150 kDa c-fms gene product and belongs to immunoglobulin family. CSF-1 signaling through CSF-1R regulates the proliferation and differentiation of cells in the monocytic lineage.
What is the relationship between CSF1R and leukemia?
Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Mutations in the tyrosine kinase domain have been associated with hereditary diffuse leukoencephalopathy with spheroids .
