Which cells have CD52?
Which cells have CD52?
CAMPATH-1 antigen, also known as cluster of differentiation 52 (CD52), is a glycoprotein that in humans is encoded by the CD52 gene. CD52 is present on the surface of mature lymphocytes, but not on the stem cells from which these lymphocytes were derived. It also is found on monocytes and dendritic cells.
What is the function of CD52?
CD52, a cell-surface protein of unknown function, is found on lymphocytes, neutrophils, monocytes, macrophages, and NK cells. Alemtuzumab profoundly depletes these cell lines through antibody dependent cellular cytotoxicity (ADCC), complement-dependent cytoxicity (CDC) and, possibly, direct apoptosis.
Where is CD52 expressed?
Introduction: CD52 (Campath-1 antigen), a glycoprotein of 12 amino acids anchored to glycosylphosphatidylinositol, is widely expressed on the cell surface of immune cells, such as mature lymphocytes, natural killer cells (NK), eosinophils, neutrophils, monocytes/macrophages, and dendritic cells (DCs).
What is anti CD20?
Anti-CD20 monoclonal antibodies (mAbs) are used to achieve B cell depletion, and were initially developed to treat B cell proliferative disorders, including non-Hodgkin’s lymphoma (NHL) and chronic lymphocytic leukemia (CLL).
Which is better Tysabri or Ocrevus?
Results showed that annual relapse rates were lower for Tysabri than Ocrevus, and patients on Tysabri were significantly less likely to have had any relapse after 12 or 24 months of treatment. Further analyses indicated that patients on Tysabri were at an approximately 30% lower risk of any relapse.
Is stelara anti-CD20?
Ustekinumab, sold under the brand name Stelara®, is a monoclonal antibody medication developed by Janssen Pharmaceuticals, for the treatment of Crohn’s disease, ulcerative colitis, plaque psoriasis and psoriatic arthritis, targeting both IL-12 and IL-23….Ustekinumab.
| Monoclonal antibody | |
|---|---|
| ATC code | L04AC05 (WHO) |
| Legal status |
What is the CD52 gene?
CAMPATH-1 antigen, also known as cluster of differentiation 52 (CD52), is a glycoprotein that in humans is encoded by the CD52 gene . CD52 is present on the surface of mature lymphocytes, but not on the stem cells from which these lymphocytes were derived. It also is found on monocytes and dendritic cells.
What is cdcd52 and why is it important?
CD52 is expressed on all CLL cells and indolent B-NHL cells. Alemtuzumab has been demonstrated to mediate apoptosis, CDC, and ADCC of CLL cells in vitro. CD52 is not shed, internalized, or modulated and is therefore an ideal antigen for targeted immunotherapy.
What is cdcd52 in T cell count?
CD52 is a highly expressed membrane glycoprotein and is the most prevalent marker, found on 95% of peripheral T and B cells. Alemtuzumab results in a profound and prolonged depletion of T cells, as well as B cells, natural killer cells, and monocytes. Alemtuzumab is given IV and has a half-life of 12 days.
What is cdcd52 peptide?
CD52 is a peptide of 12 amino acids, anchored to glycosylphosphatidylinositol (GPI). Since it is highly negatively charged and present on sperm cells and lymphocytes, it has been conjectured that its function is anti-adhesion, allowing cells to freely move around.
