Why is protein high in bacterial meningitis CSF?
Why is protein high in bacterial meningitis CSF?
During bacterial infection, the protein level in the CSF goes up, due to the increased numbers of replicating bacteria and body cells fighting the infection, with both of them having a high concentration of protein. High levels of lactate in CSF indicate a higher likelihood of bacterial meningitis.
What does elevated protein in CSF indicate?
An abnormal protein level in the CSF suggests a problem in the central nervous system. Increased protein level may be a sign of a tumor, bleeding, nerve inflammation, or injury. A blockage in the flow of spinal fluid can cause the rapid buildup of protein in the lower spinal area.
What causes high protein in meningitis?
CSF protein concentration may rise due to 2 factors: either an increased permeability of the blood brain barrier allowing more protein and higher molecular weight proteins to enter the CSF or proteins may be synthesised within the cerebrospinal canal by inflammatory or other invading cells.
What is normal protein level in CSF?
The normal protein range varies from lab to lab, but is typically about 15 to 60 milligrams per deciliter (mg/dL) or 0.15 to 0.6 milligrams per milliliter (mg/mL). Normal value ranges may vary slightly among different laboratories. Talk to your health care provider about the meaning of your specific test results.
What is normal CSF protein?
The normal protein range varies from lab to lab, but is typically about 15 to 60 milligrams per deciliter (mg/dL) or 0.15 to 0.6 milligrams per milliliter (mg/mL).
What are the CSF findings in meningitis?
In people with meningitis, the CSF often shows a low sugar (glucose) level along with an increased white blood cell count and increased protein. CSF analysis may also help your doctor identify which bacterium caused the meningitis.
What is a normal CSF protein level in bacterial meningitis?
The CSF protein level (reference range, 20-50 mg/dL) is usually elevated in bacterial meningitis.
What does it mean when CSF protein is high?
An abnormal protein level in the CSF suggests a problem in the central nervous system. Increased protein level may be a sign of a tumor, bleeding, nerve inflammation, or injury. A blockage in the flow of spinal fluid can cause the rapid buildup of protein in the lower spinal area.
What is the protein content of CSF in NMO?
Total protein and glucose content. Total CSF protein levels are often elevated in NMO patients. 119 In one longitudinal study, fluctuations in CSF protein concentration correlated with disease exacerbations, ranging between 209 and 640 mg/dl during relapses, and between 33 and 63 mg/dl during remissions.
What is the pathophysiology of bacterial meningitis?
Bacterial meningitis leads to a more permeable blood brain barrier (due to increased inflammation). Protein leaks into the subarachnoid space from the blood, resulting in markedly increased CSF protein levels. What is Hypoglycorrhachia?
