What cells do bisphosphonates work on?
What cells do bisphosphonates work on?
Bisphosphonates are drugs that target areas of higher bone turnover. The osteoclast cells, which break down old bone, absorb the bisphosphonate drug. Their activity is slowed down. This reduces bone breakdown.
How does bisphosphonates treat osteoporosis?
Bisphosphonates slow bone resorption by reducing osteoclast function. Many studies have shown that this class of medication can improve bone density and reduce the risk of fracture in patients with a reduced bone density.
How do bisphosphonates help osteoporosis?
How do bisphosphonates treat osteoporosis?
What is farnesyl pyrophosphate synthase (FPPS)?
Introduction Farnesyl pyrophosphate synthase (FPPS) is a key branch point enzyme in the mevalonate pathway, the exclusive route of isoprenoid production in animals, involved in cholesterol biosynthesis and synthesis of intermediates important for intracellular signalling and growth control [1].
How do nitrogen-containing Bisphosphonates inhibit farnesyl pyrophosphate synthase?
As elegantly illustrated in recent studies, nitrogen-containing bisphosphonates bind to and inhibit the activity of farnesyl pyrophosphate synthase, a key regulatory enzyme in the mevalonic acid pathway critical to the production of cholesterol, other sterols, and isoprenoid lipids , (Figure 2, A).
How do bisphosphonates affect osteoclasts?
ROLE IN CLINICAL PRACTICE. As aforementioned, bisphosphonates promote the apoptosis of osteoclasts actively engaged in the degradation of mineral on the bone surface. Accordingly, bisphosphonates have become the primary therapy for managing skeletal conditions characterized by increased osteoclast-mediated bone resorption.
What are the medical uses of bisphosphonates?
Their principal uses are for Paget disease of bone, myeloma, bone metastases, and osteoporosis in adults, but there has been increasing and successful application in pediatric bone diseases, notably osteogenesis imperfecta. Bisphosphonates are structural analogues of inorganic pyrophosphate but are resistant to enzymatic and chemical breakdown.
