Is piperonyl butoxide safe for humans?

Is piperonyl butoxide safe for humans?

Piperonyl butoxide (PBO) is a man-made pesticide ingredient called a synergist. PBO is low in toxicity to humans but is often combined with other pesticides like pyrethrins or pyrethroids. PBO is practically non-toxic to birds, mammals, and bees. However, it is moderately toxic to fish.

Is pyrethrin toxic to humans?

In general, pyrethrins are low in toxicity to people and other mammals. However, if it gets on your skin, it can be irritating. It can also cause tingling or numbness at the site of contact.

Is Phenothrin safe for humans?

d-phenothrin is low in toxicity when eaten, breathed in, or applied to skin or eyes. d-Phenothrin can cause vomiting, diarrhea, excess salivation, twitching, tremors, or seizures if eaten or applied to the skin. d-Phenothrin can also cause allergic skin reactions and skin sensations.

What does piperonyl butoxide do?

Piperonyl butoxide is a chemical that stops the breakdown of pyrethrins, an insecticide chemical. Piperonyl butoxide and pyrethrins topical (for the skin) is a combination medicine used to treat lice. Piperonyl butoxide and pyrethrins topical may also be used for purposes not listed in this medication guide.

Is piperonyl butoxide carcinogenic?

Based on these studies, the U.S. EPA has classified PBO as a possible human carcinogen. However, the Internal Agency for Research on Cancer (IARC) evaluated PBO and reported that it is “not classifiable as to its carcinogenicity to humans.”

Is pyrethrin safe for dogs?

The use of pyrethrins/pyrethroids is generally very safe in dogs; however, cats and fish are very sensitive to these products.

Is Phenothrin toxic to dogs?

It has increased risk of liver cancer in rats and mice in long-term exposure. It is capable of killing mosquitoes, although remains poisonous to cats and dogs, with seizures and deaths being reported due to poisoning.

Is Phenothrin the same as permethrin?

Pyrethroids are synthetic chemical insecticides that act in a similar manner to pyrethrins, which are derived from chrysanthemum flowers. Permethrin, resmethrin, and d-phenothrin (Sumithrin®) are synthetic pyrethroids commonly used in mosquito control programs to kill adult mosquitoes.

What is pyrethrins and piperonyl butoxide?

Pyrethrin and piperonyl butoxide shampoo is used to treat lice (small insects that attach themselves to the skin on the head, body, or pubic area [‘crabs’]) in adults and children 2 years of age and older. Pyrethrin and piperonyl butoxide is in a class of medications called pediculicides. It works by killing lice.

Is piperonyl butoxide safe for cats?

Piperonyl butoxide (PBO) was first developed in 1947 and is still widely used. It is usually combined with pyrethrin or rotenone preparations in ratios of 5–20:1 by weight. PBO appears very safe in companion animals, with an acute oral LD50 in the cat and dog of more than 7500 mg/kg.

Where can I find information on piperonyl butoxide?

National Pesticide Information Center 1.800.858.7378 1. PIPERONYL BUTOXIDE. GENERAL FACT SHEET. What is piperonyl butoxide (PBO) Piperonyl butoxide (PBO) is a man-made pesticide synergist. By itself, PBO is not designed to harm insects. Instead, it works with bug killers to increase their effectiveness.

Is piperonyl butoxide (PBO) an endocrine disruptor?

The EPA has evaluated PBO for its potential as an endocrine disruptor. Based on this evaluation, there was no convincing evidence of interaction with the estrogen, androgen, or thyroid pathways in mammals. Are children more sensitive to piperonyl butoxide (PBO) than adults?

Is piperonyl butoxide a banned pesticide in Europe?

A U.S. EPA restricted Use Pesticide (RUP). Not listed for use in EU countries[115]. Piperonyl butoxide is a synergist, i.e., not a pesticide itself, but enhances the properties of other chemicals.

Is piperonyl butoxide safe for dogs?

Piperonyl butoxide (PBO) was first developed in 1947 and is still widely used. It is usually combined with pyrethrin or rotenone preparations in ratios of 5–20:1 by weight. PBO appears very safe in companion animals, with an acute oral LD50 in the cat and dog of more than 7500 mg/kg.