What type of protein is band 3?
What type of protein is band 3?
membrane protein
Band 3 (SLC4A1), a membrane protein of 911 amino acids, belongs to the SLC4A family of HCO3— (and CO32-) transporters (Choi, 2012; Romero et al., 2013).
Is band 3 a transmembrane protein?
The N-glycosylated membrane domain of band 3 consists of multiple membrane spanning segments that come together to form a regulated transmembrane passage for the exchange of anions. In this article we review the structural features of the membrane domain of band 3.
What is band 3 biology?
Band 3 is the major anion HCO3−Cl− exchanger in RBC membrane. In addition, band 3 has an important structural role in the RBC membrane through the interaction of its N-terminal domain with ankyrin, band 4.2, and band 4.1 in the membrane skeleton.
What is the erythrocyte transporter protein an example of?
GLUT1, found in the plasma membrane of erythrocytes, is a classic example of a uniporter. After glucose is transported into the erythrocyte, it is rapidly phosphorylated, forming glucose-6-phosphate, which cannot leave the cell….GLUT1.
| Glucose transporter, type 1 | ||
|---|---|---|
| PubMed search | n/a | n/a |
| Wikidata | ||
| View/Edit Human |
Why is it called Band 3 protein?
Discovery. AE1 was discovered following SDS-PAGE (sodium dodecyl sulfate polyacrylamide gel electrophoresis) of erythrocyte cell membrane. The large ‘third’ band on the electrophoresis gel represented AE1, which was thus initially termed ‘Band 3’.
Do Band 3 ankyrin complexes contain actin?
Band 3 and protein 4.2 are the major components of the ankyrin complex and link their associated proteins and the lipid bilayer membrane to the spectrin cytoskeleton through ankyrin.35,36 Likewise, band 3, protein 4.2, adducin, and actin are the major components of the actin junctional (4.1) complex and link the lipid …
What is the function of spectrin?
Spectrin is crucial for maintaining the stability and structure of the cell membrane and the shape of a cell. Moreover, it contributes to diverse cell functions such as cell adhesion, cell spreading, and the cell cycle.
Does glut 1 respond to insulin?
In contrast, GLUT1 is predominantly in the PM fraction at baseline and does not change its distribution in response to insulin infusion.
