What is the ligand for L-selectin?
What is the ligand for L-selectin?
A group of O-glycosylated mucins decorated with sialic acid, termed sialomucins, represents the protein ligands for L-selectin. They are GlyCAM-1, CD34 and MAdCAM-1.
Do neutrophils have L-selectin?
L-selectin is a type I transmembrane cell adhesion molecule expressed on most circulating leukocytes, including neutrophils. There is a large body of evidence to suggest that signalling downstream of L-selectin can influence neutrophil behaviour: adhesion, migration and priming.
What is the function of selectin?
The selectins are cell surface lectins that have evolved to mediate the adhesion of white blood cells to endothelial cells and platelets under flow. They recognize fucosylated, sialylated and in some cases sulfated ligands expressed on scaffold glycoproteins serving as functional counter-receptors.
What does L-selectin stand for?
L-selectin, also known as CD62L, is a cell adhesion molecule found on leukocytes and the preimplantation embryo. It belongs to the selectin family of proteins, which recognize sialylated carbohydrate groups.
What is L-selectin shedding?
During neutrophil recruitment and activation, L-selectin is rapidly shed from the cell surface. Several studies describe this process as a mechanism to reduce adhesion receptor density to allow neutrophil migration following extravasation.
Is P-selectin a protein?
P-selectin (PADGEM, GMP-140, CD62) is a transmembrane protein specific to alpha granules of platelets and Weibel-Palade bodies of endotheial cells. Upon stimulation of these cells, P-selectin is translocated to the plasma membrane where it functions as a receptor for monocytes and neutrophils.
Is P-selectin a cytokine?
The P-selectin-dependent cytokine secretion shown in this study may be involved in the process of leukocyte transmigration.
Is L-selectin a cytokine?
L-selectin is expressed by all leukocytes except by activated, memory lymphocytes (35,44,45). IFNa is the only immunomodulatory cytokine so far which increases the cell-surface density of L-selectin and this correlates with increased mRNA steady-state levels and enhanced binding of cells to L-selectin ligands (48).
Where are L selectins found?
chromosome 1
The human L-selectin gene (sell) is located on the long arm of chromosome 1 (1q24. 2), and is arranged in tandem with its family members (in the order: L-, P-, and E-selectin). L-selectin consists of ten exons spanning a region of ~21.0 kb.
What is selectin inflammation?
During inflammation, selectins enable the initial attachment of leukocytes from the bloodstream, which causes their downstream movement along the endothelium via adhesive interactions referred to as leukocyte rolling.
What type of protein is selectin?
A family of carbohydrate-binding proteins or lectins, termed selectins, has been discovered and shown to be involved directly in these processes. The three known selectins, termed L-, E- and P-selectins, have domains homologous to other Ca(2+)-dependent (C-type) lectins.
