What is Defitelio used for?
What is Defitelio used for?
Defitelio is used to treat severe veno-occlusive disease (VOD) in adults and children who have undergone chemotherapy and a stem-cell transplant. VOD happens when blood vessels in the liver become blocked, which decreases blood flow and can lead to liver damage.
What is defibrotide sodium?
Defibrotide sodium is an oligonucleotide mixture with profibrinolytic properties. The chemical name of defibrotide sodium is polydeoxyribonucleotide, sodium salt.
How long does Defibrotide take to work?
Defibrotide: administration, duration of use, actual given dose. The median delay to start DF was 1 day after the diagnosis of VOD (range 0–12 days). The median duration of treatment with DF was 17 days (range 1–83 days).
How do you administer a Defibrotide?
The recommended dosage of DEFITELIO for adult and pediatric patients is 6.25 mg/kg every 6 hours given as a 2- hour intravenous infusion. The dose should be based on patient’s baseline body weight, defined as the patient’s weight prior to the preparative regimen for HSCT. Administer DEFITELIO for a minimum of 21 days.
How much does Defibrotide cost?
The cost for Defitelio intravenous solution (80 mg/mL) is around $9,994 for a supply of 25 milliliters, depending on the pharmacy you visit….Intravenous Solution.
| Quantity | Per unit | Price |
|---|---|---|
| 25 (10 x 2.5 milliliters) | $399.78 | $9,994.42 |
Is Defibrotide an anticoagulant?
Defibrotide (DF) is a polydeoxyribonucleotide that has been found to have anti-thrombotic, anti-ischaemic and thrombolytic properties without causing significant anticoagulation.
What type of drug is defibrotide?
Defibrotide injection is in a class of medications called antithrombotic agents. It works by preventing the formation of blood clots.
What does heparin do in the body?
Heparin injection is an anticoagulant. It is used to decrease the clotting ability of the blood and help prevent harmful clots from forming in blood vessels. This medicine is sometimes called a blood thinner, although it does not actually thin the blood.
Why heparin should not be taken with aspirin?
aspirin heparin Ask your doctor before using aspirin together with heparin. This can cause you to bleed more easily. You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR).
What is Defitelio injection made of?
Defitelio (defibrotide sodium) injection is a clear, light yellow to brown, sterile, preservative-free solution in a single-patient-use vial for intravenous use. Each milliliter of the injection contains 80 mg of defibrotide sodium and 10 mg of Sodium Citrate, USP, in Water for Injection, USP.
What is defdefitelio used to treat?
Defitelio is indicated for the treatment of adult and pediatric patients with hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), with renal or pulmonary dysfunction following hematopoietic stem-cell transplantation (HSCT).
What are the possible side effects of Defitelio?
These reactions include rash, urticaria and angioedema. One case of an anaphylactic reaction was reported in a patient who had previously received Defitelio. Monitor patients for hypersensitivity reactions, especially if there is a history of previous exposure.
Is Defitelio safe for hepatic VOD?
The safety of Defitelio was determined in 176 adult and pediatric patients with hepatic VOD with pulmonary and/or renal dysfunction following HSCT who were treated with Defitelio 6.25 mg/kg every 6 hours [see Clinical Studies (14)].
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