What is a transcriptome-wide association study?
What is a transcriptome-wide association study?
Transcriptome-wide association studies (TWAS) are a powerful strategy to study gene-trait associations by integrating genome-wide association studies (GWAS) with gene expression datasets. TWAS increases study power and interpretability by mapping genetic variants to genes.
What is the transcriptome of a cell?
A transcriptome is the full range of messenger RNA, or mRNA, molecules expressed by an organism. The term “transcriptome” can also be used to describe the array of mRNA transcripts produced in a particular cell or tissue type.
What are gene effects?
The genetic effects (of radiation) are inheritable changes, chiefly mutations, produced by the absorption of ionizing radiation’s. On the basis of present knowledge, these effects are additive and irreversible.
What is Mendelian randomization study?
Mendelian randomization is a method of using measured variation in genes of known function to examine the causal effect of a modifiable exposure on disease in observational studies .
What is a transcriptome profile?
Transcriptomics is defined as the study of transcriptome—the complete set of RNA, also known as expression profiling, as it is a study of the expression levels of mRNAs in a given cell population.
What is genetic reaction?
Gene–environment interaction (or genotype–environment interaction or GxE or G×E) is when two different genotypes respond to environmental variation in different ways. A norm of reaction is a graph that shows the relationship between genes and environmental factors when phenotypic differences are continuous.
What are examples of genetic effects?
Examples include cystic fibrosis, phenylketonuria, hemochromatosis, Bloom’s syndrome, and ataxia-telangietasia. The X-linked recessive diseases are due to mutations in genes located on the X chromosome and include Duchenne’s muscular dystrophy, Fabry’s disease, steroid sulfatase deficiency, and ocular albinism.
