What is Andexanet alfa?
What is Andexanet alfa?
Andexanet alfa is a recombinant, modified human factor Xa decoy protein developed to reverse the effects of factor Xa inhibitors including enoxaparin, apixaban, and rivaroxaban.
How many patients are enrolled in the Andexanet alfa trial?
Approximately 900 patients are planned to be enrolled in the study. A Randomized Clinical Trial of Andexanet Alfa [Andexanet Alfa for Injection] in Acute Intracranial Hemorrhage in Patients Receiving an Oral Factor Xa Inhibitor
What is the function of andexanet?
Andexanet is a recombinant modified factor Xa protein that lacks the enzymatic activity of factor Xa. As such, it acts as a decoy protein binding and inactivating factor Xa inhibitors with high affinity; in so doing, it reverses their anticoagulant effects.
Does Andexanet alfa for the reversal of factor Xa inhibitor activity work?
Andexanet Alfa for the Reversal of Factor Xa Inhibitor Activity 1 Results. Among the apixaban-treated participants, anti–factor Xa activity was reduced by 94%… 2 Conclusions. Andexanet reversed the anticoagulant activity of apixaban and rivaroxaban in older… 3 Methods. The ANNEXA-A and ANNEXA-R trials were randomized, double-blind,…
