What are the 3 drug transport systems?

What are the 3 drug transport systems?

The five groups of drug transports are as follows: (1) organic ion transporter superfamily, (2) ATP-dependent transporter superfamily, (3) peptide transporter family, (4) organic anion transporting polypeptide family originated from liver and (5) amino acid-polyamine-choline transporter superfamily.

What are transporters in pharmacology?

Transporters (membrane transport/carrier proteins) are specialized membrane-spanning proteins that assist in the movement of ions, peptides, small molecules, lipids and macromolecules across a biological membrane.

Are transporters drug targets?

Utilizing transporters as drug targets may require indirect methods, such as developing molecules that function as potentiators or correctors, or developing substrates that bypass the transporter. Some currently marketed drugs, including diuretics, neuropsychiatric drugs and antidiabetic drugs, target SLC transporters.

Which transporter in Git is responsible for drug efflux?

Table I. Efflux transporters expressed in the intestine and liver include P-glycoprotein (Pgp, ABCB1), bile salt export pump (BSEP, ABCB11), multidrug resistance proteins (MRP1- 6, ABCC1-6), and breast cancer resistance protein (BCRP, ABCG2), all members of the ATP-Binding Cassette superfamily (14,26).

What do uptake transporters do?

Drug uptake transporters are membrane proteins responsible for the trans-membrane transport of endo- and xenobiotics, including numerous drugs. They are important for the uptake of drugs into target tissues or into organs for metabolism and excretion.

What is drug distribution?

Drug distribution is the disbursement of an unmetabolized drug as it moves through the body’s blood and tissues. The efficacy or toxicity of a drug depends on the distribution in specific tissues and in part explains the lack of correlation between plasma levels and the effects that are seen.

What are the different types of transporter?

The different modes of transport are air, water, and land transport, which includes Rails or railways, road and off-road transport. Other modes also exist, including pipelines, cable transport, and space transport.

What are the three types of simple transporters and how do they work?

Three common types of passive transport include simple diffusion, osmosis, and facilitated diffusion. Simple Diffusion is the movement of particles from an area of higher concentration to an area of lower concentration. A couple of common examples will help to illustrate this concept.

How do drugs act through transporters?

Because transporter proteins have saturable binding sites, co-administered drugs may inhibit transporters and can thereby influence the uptake or efflux of another drug. This can lead to reduced excretion or metabolism of drugs and as a result increased internal exposure, which may lead to drug induced toxicity.

Do SLC transporters require ATP?

The SLC superfamily does not contain active transporters that directly use the energy released by ATP hydrolysis to drive the transport of substances against their concentration gradient. Rather, these proteins act as passive facilitative transporters or secondary active transporters [[29]].

What are uptake transporters?

Abstract. Drug uptake transporters are membrane proteins responsible for the trans-membrane transport of endo- and xenobiotics, including numerous drugs. They are important for the uptake of drugs into target tissues or into organs for metabolism and excretion.

What are influx transporters?

Transporters are membrane-bound proteins that play an important role in active transport of nutrients or xenobiotics. On the other hand, influx transporters enable translocation of essential nutrients and xenobiotics across cell membranes.

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