Can GLUT2 transport fructose?

Can GLUT2 transport fructose?

Dietary fructose is transported across the apical membrane by a specific facilitative transporter, GLUT5 (11). GLUT2 in the basolateral membrane, however, transports both glucose and fructose, providing a common exit pathway into the blood (12).

Which glut transporter is used for fructose absorption?

GLUT5
Facilitated Glucose Transporter 5 Fructose absorption is mediated by GLUT5 (140,161,162), which is an apically expressed, transmembrane protein that facilitates fructose movement down a chemical gradient.

What is the role of GLUT2?

GLUT2 is the major glucose transporter inβ -cells of pancreatic islets and hepatocytes. In both cell types, GLUT2 mediates the facilitated diffusion of glucose across the cell membranes, and then intracellular glucose metabolism is initiated by the glucose-phosphorylating enzyme, hexokinase IV or glucokinase.

What organ has the transporter for fructose metabolism?

The remaining fructose is released across the basolateral membrane into portal circulation down the concentration gradient by GLUT2. In this conceptual model, the small intestine passively transport fructose to portal circulation and the liver is a major organ for fructose metabolism.

Is GLUT2 insulin sensitive?

Furthermore, insulin resistance provoked a loss of control by insulin of GLUT2 membrane trafficking, a pathological consequence of the long-term consumption of a fructose-rich or high-fat diet. Insulin sensitivity and glucose tolerance are important factors in the regulation of intestinal GLUT2 trafficking.

Why is GLUT2 appropriate for hepatocytes?

GLUT2 is the major glucose transporter of hepatocytes in rodents and humans [19, 49]. The generally accepted role of this transporter is to take up glucose during the absorptive phase and to release it in the blood during fasting.

What transporter transports fructose?

The Main Fructose Transporter GLUT5 How does fructose move from the intestinal lumen to the blood and from there to various tissues? Fructose is transported passively across membranes by a member of the facilitative glucose transporter (GLUT) family, named GLUT5 (19, 20, 72, 98, 137).

Which transport protein is responsible for transporting fructose?

Fructose Transport GLUT5 is a 501-amino-acid transmembrane protein that transports fructose and glucose molecules. Fructose is transported from the enterocyte into the portal circulation via the basolateral membrane GLUT2 transporter. Fructose is not as well absorbed as is glucose.

Does GLUT2 need insulin?

In pancreatic beta cells, GLUT2 is required for glucose-stimulated insulin secretion. In hepatocytes, suppression of GLUT2 expression revealed the existence of an unsuspected glucose output pathway that may depend on a membrane traffic-dependent mechanism.

Is GLUT2 responsive to insulin?

What transport transports fructose?

facilitated diffusion
GLUT5 is a fructose transporter expressed on the apical border of enterocytes in the small intestine. GLUT5 allows for fructose to be transported from the intestinal lumen into the enterocyte by facilitated diffusion due to fructose’s high concentration in the intestinal lumen.

Which enzyme breaks down fructose?

Sucrase is the intestinal enzyme that aids in the breakdown of sucrose (table sugar) into glucose and fructose, which are used by the body as fuel.